{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Haslbauer JD"],"funding":["Fondation Botnar"],"pubmed_abstract":["Although initial immunophenotypical studies on peripheral blood and bronchoalveolar lavage samples have provided a glimpse into the immunopathology of COVID-19, analyses of pulmonary draining lymph nodes are currently scarce. 22 lethal COVID-19 cases and 28 controls were enrolled in this study. Pulmonary draining lymph nodes (mediastinal, tracheal, peribronchial) were collected at autopsy. Control lymph nodes were selected from a range of histomorphological sequelae [unremarkable histology, infectious mononucleosis, follicular hyperplasia, non-SARS related HLH, extrafollicular plasmablast activation, non-SARS related diffuse alveolar damage (DAD), pneumonia]. Samples were mounted on a tissue microarray and underwent immunohistochemical staining for a selection of immunological markers and "],"journal":["Frontiers in immunology"],"pagination":["763098"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8710573"],"repository":["biostudies-literature"],"pubmed_title":["Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19."],"pmcid":["PMC8710573"],"pubmed_authors":["Zinner C","Bassetti S","Stalder AK","Menter T","Matter MS","Mertz KD","Haslbauer JD","Schneeberger J","Went P","Tzankov A"],"additional_accession":[]},"is_claimable":false,"name":"Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19.","description":"Although initial immunophenotypical studies on peripheral blood and bronchoalveolar lavage samples have provided a glimpse into the immunopathology of COVID-19, analyses of pulmonary draining lymph nodes are currently scarce. 22 lethal COVID-19 cases and 28 controls were enrolled in this study. Pulmonary draining lymph nodes (mediastinal, tracheal, peribronchial) were collected at autopsy. Control lymph nodes were selected from a range of histomorphological sequelae [unremarkable histology, infectious mononucleosis, follicular hyperplasia, non-SARS related HLH, extrafollicular plasmablast activation, non-SARS related diffuse alveolar damage (DAD), pneumonia]. Samples were mounted on a tissue microarray and underwent immunohistochemical staining for a selection of immunological markers and ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-07T23:30:56.413Z","creation":"2022-02-11T14:36:55.446Z"},"accession":"S-EPMC8710573","cross_references":{"pubmed":["34966385"],"doi":["10.3389/fimmu.2021.763098"]}}