{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Santiago Santana JM"],"funding":["NIDDK NIH HHS","NIMHD NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["112995"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8713435"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["400"],"pubmed_abstract":["<h4>Background</h4>There is growing recognition for a reciprocal, bidirectional link between anxiety disorders and obesity. Although the mechanisms linking obesity and anxiety remain speculative, this bidirectionality suggests shared pathophysiological processes. Neuroinflammation and oxidative damage are implicated in both pathological anxiety and obesity. This study investigates the relative contribution of comorbid diet-induced obesity and stress-induced anxiety to neuroinflammation and oxidative stress.<h4>Methods</h4>Thirty-six (36) male Lewis rats were divided into four groups based on diet type and stress exposure: 1) control diet unexposed (CDU) and 2) exposed (CDE), 3) Western-like high-saturated fat diet unexposed (WDU) and 4) exposed (WDE). Neurobehavioral tests were performed t"],"journal":["Behavioural brain research"],"pubmed_title":["Oxidative stress and neuroinflammation in a rat model of co-morbid obesity and psychogenic stress."],"pmcid":["PMC8713435"],"funding_grant_id":["P20 MD001632","P20 MD006988","R21 DK124727","R25 GM060507"],"pubmed_authors":["Arroyo Torres Y","Santiago Santana JM","Ontiveros-Angel P","Cruz Gonzalez AY","Aponte Boria E","Vega-Torres JD","Bin Lee J","Figueroa JD","Zabala Ortiz D","Alvarez Carmona C"],"additional_accession":[]},"is_claimable":false,"name":"Oxidative stress and neuroinflammation in a rat model of co-morbid obesity and psychogenic stress.","description":"<h4>Background</h4>There is growing recognition for a reciprocal, bidirectional link between anxiety disorders and obesity. Although the mechanisms linking obesity and anxiety remain speculative, this bidirectionality suggests shared pathophysiological processes. Neuroinflammation and oxidative damage are implicated in both pathological anxiety and obesity. This study investigates the relative contribution of comorbid diet-induced obesity and stress-induced anxiety to neuroinflammation and oxidative stress.<h4>Methods</h4>Thirty-six (36) male Lewis rats were divided into four groups based on diet type and stress exposure: 1) control diet unexposed (CDU) and 2) exposed (CDE), 3) Western-like high-saturated fat diet unexposed (WDU) and 4) exposed (WDE). Neurobehavioral tests were performed t","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-25T22:56:42.079Z","creation":"2025-04-06T09:15:18.829Z"},"accession":"S-EPMC8713435","cross_references":{"pubmed":["33301815"],"doi":["10.1016/j.bbr.2020.112995"]}}