{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pijewska E"],"funding":["Fundacja na rzecz Nauki                         Polskiej","NEI NIH HHS","National Eye Institute","University of California Davis School of                         Medicine"],"pagination":["7849-7871"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8713677"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(12)"],"pubmed_abstract":["Several specialized retinal optical coherence tomography (OCT) acquisition and processing methods have been recently developed to allow <i>in vivo</i> probing of light-evoked photoreceptors function, focusing on measurements in individual photoreceptors (rods and cones). Recent OCT investigations in humans and experimental animals have shown that the outer segments in dark-adapted rods and cones elongate in response to the visible optical stimuli that bleach fractions of their visual photopigment. We have previously successfully contributed to these developments by implementing OCT intensity-based \"optoretinograms\" (ORG), the paradigm of using near-infrared OCT (NIR OCT) to measure bleaching-induced back-scattering and/or elongation changes of photoreceptors in the eye <i>in vivo</i>. In p"],"journal":["Biomedical optics express"],"pubmed_title":["Extraction of phase-based optoretinograms (ORG) from serial B-scans acquired over tens of seconds by mouse retinal raster scanning OCT system."],"pmcid":["PMC8713677"],"funding_grant_id":["R01 EY026556","POIR.04.04.00-00-2070/16-00","EY026556","EY012576","EY031098","R01 EY031098","P30 EY012576","UC Davis Eye Center Departmental Fund"],"pubmed_authors":["Szkulmowski M","Pijewska E","Meina M","Meleppat RK","Zawadzki RJ","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"Extraction of phase-based optoretinograms (ORG) from serial B-scans acquired over tens of seconds by mouse retinal raster scanning OCT system.","description":"Several specialized retinal optical coherence tomography (OCT) acquisition and processing methods have been recently developed to allow <i>in vivo</i> probing of light-evoked photoreceptors function, focusing on measurements in individual photoreceptors (rods and cones). Recent OCT investigations in humans and experimental animals have shown that the outer segments in dark-adapted rods and cones elongate in response to the visible optical stimuli that bleach fractions of their visual photopigment. We have previously successfully contributed to these developments by implementing OCT intensity-based \"optoretinograms\" (ORG), the paradigm of using near-infrared OCT (NIR OCT) to measure bleaching-induced back-scattering and/or elongation changes of photoreceptors in the eye <i>in vivo</i>. In p","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-07-11T03:14:08.265Z","creation":"2026-07-11T03:07:57.98Z"},"accession":"S-EPMC8713677","cross_references":{"pubmed":["35003871"],"doi":["10.1364/boe.439900","10.1364/BOE.439900"]}}