{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":65,"searchCount":0},"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Szymankiewicz M"],"pubmed_abstract":["Invasive <i>Candida glabrata</i> infections are not common complications after radical cystoprostatectomy. Furthermore, resistance to echinocandins arising during the course of a patient's treatment is rarely recognised. We described a case of development of echinocandin resistance in a patient with muscle-invasive bladder cancer (pT2b N0 M0, high grade) diagnosis, subjected to radical cystoprostatectomy and exposed to echinocandins. A male patient with a previous surgical history after a traffic accident, who was operated on due to bladder cancer, underwent an episode of candidemia and mixed postoperative wound and urinary tract infection caused by <i>C. glabrata</i> and extended spectrum β-lactamase (ESBL)-producing <i>Escherichia coli</i> during hospital treatment. The patient was started on caspofungin. Repeat blood cultures showed clearance of the bloodstream infection; however, infection persisted at the surgical site. Resistance to echinocandins developed within 2 months from the day of initiation of therapy with caspofungin in the <i>C. glabrata</i> strain obtained from the surgical site. The isolates sequentially obtained during the patient's treatment demonstrated resistance to echinocandins due to the mutation in hotspot 1 <i>FKS2</i>. Although resistance to echinocandins is relatively rare, it should be considered in oncological patients with increased complexity of treatment and intestinal surgery."],"journal":["Frontiers in oncology"],"pagination":["794235"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8714647"],"repository":["biostudies-literature"],"pubmed_title":["Case Report: Echinocandin-Resistance <i>Candida glabrata FKS</i> Mutants From Patient Following Radical Cystoprostatectomy Due to Muscle-Invasive Bladder Cancer."],"pmcid":["PMC8714647"],"pubmed_authors":["Nowikiewicz T","Szymankiewicz M","Kamecki K","Oledzka G","Jarzynka S","Koryszewska-Baginska A"],"view_count":["65"],"additional_accession":[]},"is_claimable":false,"name":"Case Report: Echinocandin-Resistance <i>Candida glabrata FKS</i> Mutants From Patient Following Radical Cystoprostatectomy Due to Muscle-Invasive Bladder Cancer.","description":"Invasive <i>Candida glabrata</i> infections are not common complications after radical cystoprostatectomy. Furthermore, resistance to echinocandins arising during the course of a patient's treatment is rarely recognised. We described a case of development of echinocandin resistance in a patient with muscle-invasive bladder cancer (pT2b N0 M0, high grade) diagnosis, subjected to radical cystoprostatectomy and exposed to echinocandins. A male patient with a previous surgical history after a traffic accident, who was operated on due to bladder cancer, underwent an episode of candidemia and mixed postoperative wound and urinary tract infection caused by <i>C. glabrata</i> and extended spectrum β-lactamase (ESBL)-producing <i>Escherichia coli</i> during hospital treatment. The patient was started on caspofungin. Repeat blood cultures showed clearance of the bloodstream infection; however, infection persisted at the surgical site. Resistance to echinocandins developed within 2 months from the day of initiation of therapy with caspofungin in the <i>C. glabrata</i> strain obtained from the surgical site. The isolates sequentially obtained during the patient's treatment demonstrated resistance to echinocandins due to the mutation in hotspot 1 <i>FKS2</i>. Although resistance to echinocandins is relatively rare, it should be considered in oncological patients with increased complexity of treatment and intestinal surgery.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2024-10-19T07:07:39.962Z","creation":"2022-02-11T14:49:18.893Z"},"accession":"S-EPMC8714647","cross_references":{"pubmed":["34976835"],"doi":["10.3389/fonc.2021.794235"]}}