biostudies-literature00650Unknown11Szymankiewicz MInvasive <i>Candida glabrata</i> infections are not common complications after radical cystoprostatectomy. Furthermore, resistance to echinocandins arising during the course of a patient's treatment is rarely recognised. We described a case of development of echinocandin resistance in a patient with muscle-invasive bladder cancer (pT2b N0 M0, high grade) diagnosis, subjected to radical cystoprostatectomy and exposed to echinocandins. A male patient with a previous surgical history after a traffic accident, who was operated on due to bladder cancer, underwent an episode of candidemia and mixed postoperative wound and urinary tract infection caused by <i>C. glabrata</i> and extended spectrum β-lactamase (ESBL)-producing <i>Escherichia coli</i> during hospital treatment. The patient was started on caspofungin. Repeat blood cultures showed clearance of the bloodstream infection; however, infection persisted at the surgical site. Resistance to echinocandins developed within 2 months from the day of initiation of therapy with caspofungin in the <i>C. glabrata</i> strain obtained from the surgical site. The isolates sequentially obtained during the patient's treatment demonstrated resistance to echinocandins due to the mutation in hotspot 1 <i>FKS2</i>. Although resistance to echinocandins is relatively rare, it should be considered in oncological patients with increased complexity of treatment and intestinal surgery.Frontiers in oncology794235https://www.ebi.ac.uk/biostudies/studies/S-EPMC8714647biostudies-literatureCase Report: Echinocandin-Resistance <i>Candida glabrata FKS</i> Mutants From Patient Following Radical Cystoprostatectomy Due to Muscle-Invasive Bladder Cancer.PMC8714647Nowikiewicz TSzymankiewicz MKamecki KOledzka GJarzynka SKoryszewska-Baginska A65falseCase Report: Echinocandin-Resistance <i>Candida glabrata FKS</i> Mutants From Patient Following Radical Cystoprostatectomy Due to Muscle-Invasive Bladder Cancer.Invasive <i>Candida glabrata</i> infections are not common complications after radical cystoprostatectomy. Furthermore, resistance to echinocandins arising during the course of a patient's treatment is rarely recognised. We described a case of development of echinocandin resistance in a patient with muscle-invasive bladder cancer (pT2b N0 M0, high grade) diagnosis, subjected to radical cystoprostatectomy and exposed to echinocandins. A male patient with a previous surgical history after a traffic accident, who was operated on due to bladder cancer, underwent an episode of candidemia and mixed postoperative wound and urinary tract infection caused by <i>C. glabrata</i> and extended spectrum β-lactamase (ESBL)-producing <i>Escherichia coli</i> during hospital treatment. The patient was started on caspofungin. Repeat blood cultures showed clearance of the bloodstream infection; however, infection persisted at the surgical site. Resistance to echinocandins developed within 2 months from the day of initiation of therapy with caspofungin in the <i>C. glabrata</i> strain obtained from the surgical site. The isolates sequentially obtained during the patient's treatment demonstrated resistance to echinocandins due to the mutation in hotspot 1 <i>FKS2</i>. Although resistance to echinocandins is relatively rare, it should be considered in oncological patients with increased complexity of treatment and intestinal surgery.2021-01-01T00:00:00Z20212024-10-19T07:07:39.962Z2022-02-11T14:49:18.893ZS-EPMC87146473497683510.3389/fonc.2021.794235