{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Lin Z"],"pubmed_abstract":["Canine breast cancer (CBC) is the most common spontaneous tumor in intact female dogs, especially in developing countries. The effective anti-tumor agents or therapies for the clinical treatment of CBC are still in need. Auranofin (AF) is a gold complex that has been attested by FDA for treating human rheumatism, which has been found as a great anti-tumor agent in recent years. ICG-001 is a small molecule inhibitor of Wnt/β-catenin pathway. In the present study, we demonstrated that a combination of AF and ICG-001 could synergistically suppress the proliferation of CBC <i>in vitro</i> and <i>in vivo</i>. Moreover, the synergistical effect was related with apoptosis caused by mitochondrial damage and ROS production. In conclusion, combination of AF and ICG-001 could synergistically suppress"],"journal":["Frontiers in veterinary science"],"pagination":["772687"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8714754"],"repository":["biostudies-literature"],"pubmed_title":["Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway."],"pmcid":["PMC8714754"],"pubmed_authors":["Zhang D","Lin D","Zhang H","Lin Z","Cheng N","Lin J","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway.","description":"Canine breast cancer (CBC) is the most common spontaneous tumor in intact female dogs, especially in developing countries. The effective anti-tumor agents or therapies for the clinical treatment of CBC are still in need. Auranofin (AF) is a gold complex that has been attested by FDA for treating human rheumatism, which has been found as a great anti-tumor agent in recent years. ICG-001 is a small molecule inhibitor of Wnt/β-catenin pathway. In the present study, we demonstrated that a combination of AF and ICG-001 could synergistically suppress the proliferation of CBC <i>in vitro</i> and <i>in vivo</i>. Moreover, the synergistical effect was related with apoptosis caused by mitochondrial damage and ROS production. In conclusion, combination of AF and ICG-001 could synergistically suppress","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-04-08T09:00:06.19Z","creation":"2022-02-11T14:50:18.289Z"},"accession":"S-EPMC8714754","cross_references":{"pubmed":["34977210"],"doi":["10.3389/fvets.2021.772687"]}}