{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Yan R"],"funding":["Hangzhou Social Development of Scientific Research","National Natural Science Foundation of China","Zhejiang Province Public Welfare Technology Application Research Project"],"pubmed_abstract":["Carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) is highly prevalent and poses a significant threat to public health. In critically ill patients, gut colonization is considered to be the reservoir of recurrent CRKP infection. Therefore, eliminating CRKP carriage in the intestine is critical for preventing subsequent CRKP infection. In the present study, <i>Lactobacillus plantarum</i> LP1812, a probiotic that can inhibit CRKP <i>in vitro</i>, was used as a candidate probiotic to investigate its efficacy for CRKP anticolonization. Compared with the control, mice fed with 1×10 <sup>8</sup> CFU <i>L. plantarum</i> LP1812 exhibited significant CRKP clearance from 1×10 <sup>4</sup> CFU/mg to less than 10 CFU/mg in mice feces. Furthermore, 16S RNA gene sequencing revealed that <i>L. plant"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["804253"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8714838"],"repository":["biostudies-literature"],"pubmed_title":["Anticolonization of Carbapenem-Resistant <i>Klebsiella pneumoniae</i> by <i>Lactobacillus plantarum</i> LP1812 Through Accumulated Acetic Acid in Mice Intestinal."],"pmcid":["PMC8714838"],"pubmed_authors":["Jiang Y","Pi X","Lan P","Lu Y","Yu P","Li Q","Yan R","Wu X","Liu W","Zhou J","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Anticolonization of Carbapenem-Resistant <i>Klebsiella pneumoniae</i> by <i>Lactobacillus plantarum</i> LP1812 Through Accumulated Acetic Acid in Mice Intestinal.","description":"Carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP) is highly prevalent and poses a significant threat to public health. In critically ill patients, gut colonization is considered to be the reservoir of recurrent CRKP infection. Therefore, eliminating CRKP carriage in the intestine is critical for preventing subsequent CRKP infection. In the present study, <i>Lactobacillus plantarum</i> LP1812, a probiotic that can inhibit CRKP <i>in vitro</i>, was used as a candidate probiotic to investigate its efficacy for CRKP anticolonization. Compared with the control, mice fed with 1×10 <sup>8</sup> CFU <i>L. plantarum</i> LP1812 exhibited significant CRKP clearance from 1×10 <sup>4</sup> CFU/mg to less than 10 CFU/mg in mice feces. Furthermore, 16S RNA gene sequencing revealed that <i>L. plant","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-04-08T07:06:03.904Z","creation":"2022-02-11T14:49:28.774Z"},"accession":"S-EPMC8714838","cross_references":{"pubmed":["34976873"],"doi":["10.3389/fcimb.2021.804253"]}}