{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ferguson MA"],"funding":["NIA NIH HHS","NIMH NIH HHS"],"pagination":["380-388"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8714871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91(4)"],"pubmed_abstract":["<h4>Background</h4>Over 80% of the global population consider themselves religious, with even more identifying as spiritual, but the neural substrates of spirituality and religiosity remain unresolved.<h4>Methods</h4>In two independent brain lesion datasets (N<sub>1</sub> = 88; N<sub>2</sub> = 105), we applied lesion network mapping to test whether lesion locations associated with spiritual and religious belief map to a specific human brain circuit.<h4>Results</h4>We found that brain lesions associated with self-reported spirituality map to a brain circuit centered on the periaqueductal gray. Intersection of lesion locations with this same circuit aligned with self-reported religiosity in an independent dataset and previous reports of lesions associated with hyper-religiosity. Lesion locat"],"journal":["Biological psychiatry"],"pubmed_title":["A Neural Circuit for Spirituality and Religiosity Derived From Patients With Brain Lesions."],"pmcid":["PMC8714871"],"funding_grant_id":["K23 MH121657","R01 AG060987","T32 MH112510","R01 MH115949","L30 MH127717","R01 MH113929"],"pubmed_authors":["Cohen A","Siddiqi S","Nielsen JA","Urgesi C","Schaper FLWVJ","Ferguson MA","Merrill SM","Fabbro F","Grafman J","Fox MD"],"additional_accession":[]},"is_claimable":false,"name":"A Neural Circuit for Spirituality and Religiosity Derived From Patients With Brain Lesions.","description":"<h4>Background</h4>Over 80% of the global population consider themselves religious, with even more identifying as spiritual, but the neural substrates of spirituality and religiosity remain unresolved.<h4>Methods</h4>In two independent brain lesion datasets (N<sub>1</sub> = 88; N<sub>2</sub> = 105), we applied lesion network mapping to test whether lesion locations associated with spiritual and religious belief map to a specific human brain circuit.<h4>Results</h4>We found that brain lesions associated with self-reported spirituality map to a brain circuit centered on the periaqueductal gray. Intersection of lesion locations with this same circuit aligned with self-reported religiosity in an independent dataset and previous reports of lesions associated with hyper-religiosity. Lesion locat","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-26T13:22:59.283Z","creation":"2025-04-06T14:12:43.582Z"},"accession":"S-EPMC8714871","cross_references":{"pubmed":["34454698"],"doi":["10.1016/j.biopsych.2021.06.016"]}}