biostudies-literatureSands MNational Center for Advancing Translational SciencesNCATS NIH HHSNINDS NIH HHS100-112https://www.ebi.ac.uk/biostudies/studies/S-EPMC8716419biostudies-literatureUnknown160(1)Regenerating Family Member 3 Alpha (REG3A) is a multifunctional protein with antimicrobial activity, and primarily secreted by the intestine and pancreas. Studies have shown an increased expression of REG3A in systemic inflammatory responses to acute injury and infection, but studies investigating REG3A during the pathogenesis of ischemic stroke are limited. The aims of this study were to examine the associations between arterial expression of REG3A and other arterial inflammatory proteins implicated in stroke pathogenesis, as well as associations between REG3A and markers of poor outcome for ischemic stroke. The University of Kentucky Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC) protocol (clinicaltrials.gov NCT03153683) utilizes thrombectomy to isolate intracranial artJournal of neurochemistryAntimicrobial protein REG3A and signaling networks are predictive of stroke outcomes.PMC8716419R56 NS091146UL1TR001998UL1 TR001998Trout ALMcLouth CJSands MFrank JAFraser JFTurchan-Cholewo JStowe AMMaglinger BPennypacker KRfalseAntimicrobial protein REG3A and signaling networks are predictive of stroke outcomes.Regenerating Family Member 3 Alpha (REG3A) is a multifunctional protein with antimicrobial activity, and primarily secreted by the intestine and pancreas. Studies have shown an increased expression of REG3A in systemic inflammatory responses to acute injury and infection, but studies investigating REG3A during the pathogenesis of ischemic stroke are limited. The aims of this study were to examine the associations between arterial expression of REG3A and other arterial inflammatory proteins implicated in stroke pathogenesis, as well as associations between REG3A and markers of poor outcome for ischemic stroke. The University of Kentucky Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC) protocol (clinicaltrials.gov NCT03153683) utilizes thrombectomy to isolate intracranial art2022-01-01T00:00:00Z2022 Jan2025-04-22T10:15:00.751Z2025-04-05T23:29:24.665ZS-EPMC87164193455805910.1111/jnc.15520