{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["O'Grady BJ"],"funding":["NIA NIH HHS","NIEHS NIH HHS","NIMH NIH HHS","NINDS NIH HHS","National Institutes of Health","Chan Zuckerberg Initiative","National Science Foundation"],"pagination":["4814-4822"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8717820"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(24)"],"pubmed_abstract":["Fabrication of microfluidic devices by photolithography generally requires specialized training and access to a cleanroom. As an alternative, 3D printing enables cost-effective fabrication of microdevices with complex features that would be suitable for many biomedical applications. However, commonly used resins are cytotoxic and unsuitable for devices involving cells. Furthermore, 3D prints are generally refractory to elastomer polymerization such that they cannot be used as master molds for fabricating devices from polymers (<i>e.g.</i> polydimethylsiloxane, or PDMS). Different post-print treatment strategies, such as heat curing, ultraviolet light exposure, and coating with silanes, have been explored to overcome these obstacles, but none have proven universally effective. Here, we show"],"journal":["Lab on a chip"],"pubmed_title":["Rapid prototyping of cell culture microdevices using parylene-coated 3D prints."],"pmcid":["PMC8717820"],"funding_grant_id":["RF1 MH123971","T32 AG058524","T32AG058524","T32 ES007028","T32ES007028","R21NS116257","2018-191850","R21 NS116257","1706155","R61 NS112445","R61NS112445","RF1MH123971","R01NS110665","R01 NS110665","2033800"],"pubmed_authors":["Florian DC","Bellan LM","Lowen GB","Wikswo JP","Kim H","Guelcher SA","Geuy MD","Fitzgerald ML","Bute NN","Fricker CM","Balotin KM","O'Grady BJ","Lippmann ES","Allchin ER","Scott TE"],"additional_accession":[]},"is_claimable":false,"name":"Rapid prototyping of cell culture microdevices using parylene-coated 3D prints.","description":"Fabrication of microfluidic devices by photolithography generally requires specialized training and access to a cleanroom. As an alternative, 3D printing enables cost-effective fabrication of microdevices with complex features that would be suitable for many biomedical applications. However, commonly used resins are cytotoxic and unsuitable for devices involving cells. Furthermore, 3D prints are generally refractory to elastomer polymerization such that they cannot be used as master molds for fabricating devices from polymers (<i>e.g.</i> polydimethylsiloxane, or PDMS). Different post-print treatment strategies, such as heat curing, ultraviolet light exposure, and coating with silanes, have been explored to overcome these obstacles, but none have proven universally effective. Here, we show","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-04T19:52:51.314Z","creation":"2025-04-04T19:52:51.314Z"},"accession":"S-EPMC8717820","cross_references":{"pubmed":["34787148"],"doi":["10.1039/d1lc00744k"]}}