{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Strasser B"],"funding":["Austrian Science Fund FWF","NIBIB NIH HHS","NICHD NIH HHS","NCI NIH HHS","National Institute of Child Health and Human Development"],"pagination":["e4621"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8717863"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(1)"],"pubmed_abstract":["MR spectroscopic imaging (MRSI) noninvasively maps the metabolism of human brains. In particular, the imaging of D-2-hydroxyglutarate (2HG) produced by glioma isocitrate dehydrogenase (IDH) mutations has become a key application in neuro-oncology. However, the performance of full field-of-view MRSI is limited by B<sub>0</sub> spatial nonuniformity and lipid artifacts from tissues surrounding the brain. Array coils that multiplex RF-receive and B<sub>0</sub> -shim electrical currents (AC/DC mixing) over the same conductive loops provide many degrees of freedom to improve B<sub>0</sub> uniformity and reduce lipid artifacts. AC/DC coils are highly efficient due to compact design, requiring low shim currents (<2 A) that can be switched fast (0.5 ms) with high interscan reproducibility (10% coe"],"journal":["NMR in biomedicine"],"pubmed_title":["Improving D-2-hydroxyglutarate MR spectroscopic imaging in mutant isocitrate dehydrogenase glioma patients with multiplexed RF-receive/B<sub>0</sub> -shim array coils at 3 T."],"pmcid":["PMC8717863"],"funding_grant_id":["R21 EB017338","J 4124-N36","HD099846","R01 CA211080","HD093578","1R01CA211080","U24 EB028984","R01 HD085813","R01 HD093578","R01 CA255479","J 4124","R01 HD099846","2P50CA165962","P50 CA165962","HD085813","R00 EB021349","1R01CA255479"],"pubmed_authors":["Dietrich J","Batchelor TT","Moser P","Andronesi OC","White J","Stockmann JP","Arango NS","Strasser B","Gagoski B","Thapa B","Li X","van der Kouwe A","Bogner W","Adalsteinsson E","Small J","Cahill DP"],"additional_accession":[]},"is_claimable":false,"name":"Improving D-2-hydroxyglutarate MR spectroscopic imaging in mutant isocitrate dehydrogenase glioma patients with multiplexed RF-receive/B<sub>0</sub> -shim array coils at 3 T.","description":"MR spectroscopic imaging (MRSI) noninvasively maps the metabolism of human brains. In particular, the imaging of D-2-hydroxyglutarate (2HG) produced by glioma isocitrate dehydrogenase (IDH) mutations has become a key application in neuro-oncology. However, the performance of full field-of-view MRSI is limited by B<sub>0</sub> spatial nonuniformity and lipid artifacts from tissues surrounding the brain. Array coils that multiplex RF-receive and B<sub>0</sub> -shim electrical currents (AC/DC mixing) over the same conductive loops provide many degrees of freedom to improve B<sub>0</sub> uniformity and reduce lipid artifacts. AC/DC coils are highly efficient due to compact design, requiring low shim currents (<2 A) that can be switched fast (0.5 ms) with high interscan reproducibility (10% coe","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-26T13:26:15.657Z","creation":"2025-04-06T14:14:18.657Z"},"accession":"S-EPMC8717863","cross_references":{"pubmed":["34609036"],"doi":["10.1002/nbm.4621"]}}