biostudies-literatureStrasser BAustrian Science Fund FWFNIBIB NIH HHSNICHD NIH HHSNCI NIH HHSNational Institute of Child Health and Human Developmente4621https://www.ebi.ac.uk/biostudies/studies/S-EPMC8717863biostudies-literatureUnknown35(1)MR spectroscopic imaging (MRSI) noninvasively maps the metabolism of human brains. In particular, the imaging of D-2-hydroxyglutarate (2HG) produced by glioma isocitrate dehydrogenase (IDH) mutations has become a key application in neuro-oncology. However, the performance of full field-of-view MRSI is limited by B<sub>0</sub> spatial nonuniformity and lipid artifacts from tissues surrounding the brain. Array coils that multiplex RF-receive and B<sub>0</sub> -shim electrical currents (AC/DC mixing) over the same conductive loops provide many degrees of freedom to improve B<sub>0</sub> uniformity and reduce lipid artifacts. AC/DC coils are highly efficient due to compact design, requiring low shim currents (<2 A) that can be switched fast (0.5 ms) with high interscan reproducibility (10% coeNMR in biomedicineImproving D-2-hydroxyglutarate MR spectroscopic imaging in mutant isocitrate dehydrogenase glioma patients with multiplexed RF-receive/B<sub>0</sub> -shim array coils at 3 T.PMC8717863R21 EB017338J 4124-N36HD099846R01 CA211080HD0935781R01CA211080U24 EB028984R01 HD085813R01 HD093578R01 CA255479J 4124R01 HD0998462P50CA165962P50 CA165962HD085813R00 EB0213491R01CA255479Dietrich JBatchelor TTMoser PAndronesi OCWhite JStockmann JPArango NSStrasser BGagoski BThapa BLi Xvan der Kouwe ABogner WAdalsteinsson ESmall JCahill DPfalseImproving D-2-hydroxyglutarate MR spectroscopic imaging in mutant isocitrate dehydrogenase glioma patients with multiplexed RF-receive/B<sub>0</sub> -shim array coils at 3 T.MR spectroscopic imaging (MRSI) noninvasively maps the metabolism of human brains. In particular, the imaging of D-2-hydroxyglutarate (2HG) produced by glioma isocitrate dehydrogenase (IDH) mutations has become a key application in neuro-oncology. However, the performance of full field-of-view MRSI is limited by B<sub>0</sub> spatial nonuniformity and lipid artifacts from tissues surrounding the brain. Array coils that multiplex RF-receive and B<sub>0</sub> -shim electrical currents (AC/DC mixing) over the same conductive loops provide many degrees of freedom to improve B<sub>0</sub> uniformity and reduce lipid artifacts. AC/DC coils are highly efficient due to compact design, requiring low shim currents (<2 A) that can be switched fast (0.5 ms) with high interscan reproducibility (10% coe2022-01-01T00:00:00Z2022 Jan2025-04-26T13:26:15.657Z2025-04-06T14:14:18.657ZS-EPMC87178633460903610.1002/nbm.4621