biostudies-literatureArc-Chagnaud CInstituto de Salud Carlos IIIMinisterio de Ciencia e InnovaciónMontana Department of AgricultureAdvanced Foods and Materials CanadaFundació la Marató de TV3Fundación General CSICGeneralitat ValencianaEuropean Regional Development Fund1879-1896https://www.ebi.ac.uk/biostudies/studies/S-EPMC8718080biostudies-literatureUnknown12(6)<h4>Background</h4>Frailty is a major age-associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine dinucleotide phosphate (NADPH) that is highly dependent on glucose 6-P dehydrogenase (G6PD). The G6PD-overexpressing mouse (G6PD-Tg) is protected against metabolic stresses. Our aim was to examine whether this protection delays frailty.<h4>Methods</h4>Old wild-type (WT) and G6PD-Tg mice were evaluated longitudinally in terms of frailty. Indirect calorimetry, transcriptomic profile, and different skeletal muscle quality markers and muscle regenerative capacity were also investigated.<h4>Results</h4>The percentage of frail mice was significantly lower in the G6PD-Tg thJournal of cachexia, sarcopenia and muscleGlucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage.PMC8718080202033CB16/10/00435Arc-Chagnaud CSerna EGomez-Cabrera MCGarcia-Dominguez EVina JCorreas AGChopard AMunoz-Canoves PSebastia VSalvador-Pascual AFernandez-Marcos PJOlaso-Gonzalez GBrioche TSerrano ALSerrano MfalseGlucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage.<h4>Background</h4>Frailty is a major age-associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine dinucleotide phosphate (NADPH) that is highly dependent on glucose 6-P dehydrogenase (G6PD). The G6PD-overexpressing mouse (G6PD-Tg) is protected against metabolic stresses. Our aim was to examine whether this protection delays frailty.<h4>Methods</h4>Old wild-type (WT) and G6PD-Tg mice were evaluated longitudinally in terms of frailty. Indirect calorimetry, transcriptomic profile, and different skeletal muscle quality markers and muscle regenerative capacity were also investigated.<h4>Results</h4>The percentage of frail mice was significantly lower in the G6PD-Tg th2021-01-01T00:00:00Z2021 Dec2026-05-09T11:56:46.743Z2022-02-11T15:04:08.992ZS-EPMC87180803470438610.1002/jcsm.12792