{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Riaz S"],"funding":["Norges Forskningsråd","Universitetet i Bergen","Innovationsfonden"],"pubmed_abstract":["Efforts to develop broadly protective vaccines against pathogenic <i>Escherichia coli</i> are ongoing. A potential antigen candidate for vaccine development is the metalloprotease YghJ, or SslE. YghJ is a conserved mucinase that is immunogenic, heavily glycosylated, and produced by most pathogenic <i>E. coli</i>. To develop efficacious YghJ-based vaccines, there is a need to investigate to what extent potentially protective antibody responses target glycosylated epitopes in YghJ and to describe variations in the quality of YghJ glycosylation in the <i>E. coli</i> population. In this study we estimated the proportion of anti-YghJ IgA antibodies that targeted glycosylated epitopes in serum and intestinal lavage samples from 21 volunteers experimentally infected with wild-type enterotoxigenic"],"journal":["Frontiers in immunology"],"pagination":["760135"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8718676"],"repository":["biostudies-literature"],"pubmed_title":["Characterization of Glycosylation-Specific Systemic and Mucosal IgA Antibody Responses to <i>Escherichia coli</i> Mucinase YghJ (SslE)."],"pmcid":["PMC8718676"],"pubmed_authors":["Riaz S","Thorsing M","Steinsland H","Andersen AZ","Hanevik K","Boysen A"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of Glycosylation-Specific Systemic and Mucosal IgA Antibody Responses to <i>Escherichia coli</i> Mucinase YghJ (SslE).","description":"Efforts to develop broadly protective vaccines against pathogenic <i>Escherichia coli</i> are ongoing. A potential antigen candidate for vaccine development is the metalloprotease YghJ, or SslE. YghJ is a conserved mucinase that is immunogenic, heavily glycosylated, and produced by most pathogenic <i>E. coli</i>. To develop efficacious YghJ-based vaccines, there is a need to investigate to what extent potentially protective antibody responses target glycosylated epitopes in YghJ and to describe variations in the quality of YghJ glycosylation in the <i>E. coli</i> population. In this study we estimated the proportion of anti-YghJ IgA antibodies that targeted glycosylated epitopes in serum and intestinal lavage samples from 21 volunteers experimentally infected with wild-type enterotoxigenic","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-07-16T15:33:51.678Z","creation":"2022-02-11T14:49:38.865Z"},"accession":"S-EPMC8718676","cross_references":{"pubmed":["34975849"],"doi":["10.3389/fimmu.2021.760135"]}}