{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim J"],"funding":["American Heart Association","NHLBI NIH HHS","NCI NIH HHS","National Institutes of Health"],"pagination":["60852-60864"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8720076"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(51)"],"pubmed_abstract":["Cerium oxide nanoparticles (CeONP), having potent antioxidant properties, are highly promising nanomaterials for treatment of diseases in which oxidative stress from excessive reactive oxygen species (ROS) plays a critical role in the pathogenesis and progression. However, most previously reported CeONP formulations were not efficiently cleared from the body, precluding their clinical translation. Herein, we report ultrasmall CeONP that can mitigate activation of macrophages and subsequent acute inflammation. It is found that these CeONP can effectively scavenge reactive species, inhibit macrophage activation, and minimize their recruitment and infiltration to the inflammation site, which lead to alleviation of edema and pain hypersensitivity. Moreover, we demonstrate that CeONP can be eff"],"journal":["ACS applied materials & interfaces"],"pubmed_title":["Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation."],"pmcid":["PMC8720076"],"funding_grant_id":["18PRE34030383","R01 HL 131557","R00 CA190658","R00 CA 190658","R01 HL131557"],"pubmed_authors":["Rosario-Berrios DN","Grosser T","Hsu JC","Cho-Park PF","Cormode DP","Kim J","Hong G","Mazaleuskaya L"],"additional_accession":[]},"is_claimable":false,"name":"Ultrasmall Antioxidant Cerium Oxide Nanoparticles for Regulation of Acute Inflammation.","description":"Cerium oxide nanoparticles (CeONP), having potent antioxidant properties, are highly promising nanomaterials for treatment of diseases in which oxidative stress from excessive reactive oxygen species (ROS) plays a critical role in the pathogenesis and progression. However, most previously reported CeONP formulations were not efficiently cleared from the body, precluding their clinical translation. Herein, we report ultrasmall CeONP that can mitigate activation of macrophages and subsequent acute inflammation. It is found that these CeONP can effectively scavenge reactive species, inhibit macrophage activation, and minimize their recruitment and infiltration to the inflammation site, which lead to alleviation of edema and pain hypersensitivity. Moreover, we demonstrate that CeONP can be eff","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-04T12:10:02.996Z","creation":"2025-04-04T12:10:02.996Z"},"accession":"S-EPMC8720076","cross_references":{"pubmed":["34914872"],"doi":["10.1021/acsami.1c16126"]}}