biostudies-literatureUnknown101(1)Salamonowicz-Bodzioch MThe aim of this multi-center study was to evaluate the incidence, clinical course, and risk factors for bacterial multidrug-resistant (MDR) gastrointestinal tract infections (GTI) among children undergoing allogeneic and autologous hematopoietic cell transplantation. A total number of 175 pediatric patients (aged 1-18 years), transplanted between January 2018 and December 2019, who were tested for bacterial colonization/infection were enrolled into this multi-center analysis. Episodes of MDR GTI occurred in 77/175 (44%) patients. In multivariate analysis for higher GTI incidence, the following factors were significant: matched-unrelated donor (MUD) transplantation, HLA mismatch, presence of graft-versus-host disease (GVHD), and gut GVHD. The most common GTI were Clostridium difficile (CDI)Annals of hematology191-201https://www.ebi.ac.uk/biostudies/studies/S-EPMC8720737biostudies-literatureAnalysis of incidence and risk factors of the multidrug resistant gastrointestinal tract infection in children and adolescents undergoing allogeneic and autologous hematopoietic cell transplantation: a nationwide study.PMC8720737Zaucha-Prazmo AZajac-Spychala OSega-Pondel DWeclawek-Tompol JKowalczyk JKalwak KGorczynska EWachowiak JUssowicz MDziedzic MStyczynski JGozdzik JWrobel GSalamonowicz-Bodzioch MWysocki MCzyzewski KFraczkiewicz JKazanowska BfalseAnalysis of incidence and risk factors of the multidrug resistant gastrointestinal tract infection in children and adolescents undergoing allogeneic and autologous hematopoietic cell transplantation: a nationwide study.The aim of this multi-center study was to evaluate the incidence, clinical course, and risk factors for bacterial multidrug-resistant (MDR) gastrointestinal tract infections (GTI) among children undergoing allogeneic and autologous hematopoietic cell transplantation. A total number of 175 pediatric patients (aged 1-18 years), transplanted between January 2018 and December 2019, who were tested for bacterial colonization/infection were enrolled into this multi-center analysis. Episodes of MDR GTI occurred in 77/175 (44%) patients. In multivariate analysis for higher GTI incidence, the following factors were significant: matched-unrelated donor (MUD) transplantation, HLA mismatch, presence of graft-versus-host disease (GVHD), and gut GVHD. The most common GTI were Clostridium difficile (CDI)2022-01-01T00:00:00Z2022 Jan2025-04-18T15:52:25.987Z2022-02-11T15:16:34.621ZS-EPMC87207373467400010.1007/s00277-021-04681-y