biostudies-literatureRotella MENational Institutes of HealthNIGMS NIH HHSNational Science Foundation12508-12511https://www.ebi.ac.uk/biostudies/studies/S-EPMC8722523biostudies-literatureUnknown57(93)An iron-catalyzed regioselective dicarbofunctionalization of electron-rich alkenes is described. In particular, aryl- and alkyl vinyl ethers are used as effective linchpins to couple alkyl or (fluoro)alkyl halides and sp²-hybridized Grignard nucleophiles. Preliminary results demonstrate the ability to engage thioethers as linchpins and control enantioselectivity in these transformations, an area which is largely unexplored in iron-catalyzed three-component cross-coupling reactions.Chemical communications (Cambridge, England)Fe-Catalyzed dicarbofunctionalization of electron-rich alkenes with Grignard reagents and (fluoro)alkyl halides.PMC8722523R35 GM1377971751568R35GM137797Liu LGutierrez OSar DRotella MEfalseFe-Catalyzed dicarbofunctionalization of electron-rich alkenes with Grignard reagents and (fluoro)alkyl halides.An iron-catalyzed regioselective dicarbofunctionalization of electron-rich alkenes is described. In particular, aryl- and alkyl vinyl ethers are used as effective linchpins to couple alkyl or (fluoro)alkyl halides and sp²-hybridized Grignard nucleophiles. Preliminary results demonstrate the ability to engage thioethers as linchpins and control enantioselectivity in these transformations, an area which is largely unexplored in iron-catalyzed three-component cross-coupling reactions.2021-01-01T00:00:00Z2021 Nov2025-04-03T22:45:04.048Z2024-11-21T05:54:19.232ZS-EPMC87225233475128710.1039/d1cc04619e