{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43(1)"],"submitter":["Huang J"],"pubmed_abstract":["Harmine is a β-carboline alkaloid isolated from Banisteria caapi and Peganum harmala L with various pharmacological activities, including antioxidant, anti-inflammatory, antitumor, anti-depressant, and anti-leishmanial capabilities. Nevertheless, the pharmacological effect of harmine on cardiomyocytes and heart muscle has not been reported. Here we found a protective effect of harmine on cardiac hypertrophy in spontaneously hypertensive rats in vivo. Further, harmine could inhibit the phenotypes of norepinephrine-induced hypertrophy in human embryonic stem cell-derived cardiomyocytes in vitro. It reduced the enlarged cell surface area, reversed the increased calcium handling and contractility, and downregulated expression of hypertrophy-related genes in norepinephrine-induced hypertrophy o"],"journal":["Acta pharmacologica Sinica"],"pagination":["50-63"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8724320"],"repository":["biostudies-literature"],"pubmed_title":["Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy."],"pmcid":["PMC8724320"],"pubmed_authors":["Xun ZX","Zheng QY","Liu Y","Sun N","Qin L","Li EM","Huang J","Chen HY","Xu C","Chen JX","Lu XY","Zhu WJ"],"additional_accession":[]},"is_claimable":false,"name":"Harmine is an effective therapeutic small molecule for the treatment of cardiac hypertrophy.","description":"Harmine is a β-carboline alkaloid isolated from Banisteria caapi and Peganum harmala L with various pharmacological activities, including antioxidant, anti-inflammatory, antitumor, anti-depressant, and anti-leishmanial capabilities. Nevertheless, the pharmacological effect of harmine on cardiomyocytes and heart muscle has not been reported. Here we found a protective effect of harmine on cardiac hypertrophy in spontaneously hypertensive rats in vivo. Further, harmine could inhibit the phenotypes of norepinephrine-induced hypertrophy in human embryonic stem cell-derived cardiomyocytes in vitro. It reduced the enlarged cell surface area, reversed the increased calcium handling and contractility, and downregulated expression of hypertrophy-related genes in norepinephrine-induced hypertrophy o","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-06-18T08:45:52.45Z","creation":"2025-04-06T09:41:32.947Z"},"accession":"S-EPMC8724320","cross_references":{"pubmed":["33785860"],"doi":["10.1038/s41401-021-00639-y"]}}