biostudies-literatureMeschiari MEU under the HORIZON Europe programmee054069https://www.ebi.ac.uk/biostudies/studies/S-EPMC8724593biostudies-literatureUnknown12(1)<h4>Objective</h4>The first COVID-19-19 epidemic wave was over the period of February-May 2020. Since 1 October 2020, Italy, as many other European countries, faced a second wave. The aim of this analysis was to compare the 28-day mortality between the two waves among COVID-19 hospitalised patients.<h4>Design</h4>Observational cohort study. Standard survival analysis was performed to compare all-cause mortality within 28 days after hospital admission in the two waves. Kaplan-Meier curves as well as Cox regression model analysis were used. The effect of wave on risk of death was shown by means of HRs with 95% CIs. A sensitivity analysis around the impact of the circulating variant as a potential unmeasured confounder was performed.<h4>Setting</h4>University Hospital of Modena, Italy. PatienBMJ openFirst and second waves among hospitalised patients with COVID-19 with severe pneumonia: a comparison of 28-day mortality over the 1-year pandemic in a tertiary university hospital in Italy.PMC8724593GA n. 6944397Bruzzi GTonelli RTabbi LMenozzi MBondi FManicardi LLugli MPietrangelo AAndreotti AChierego GModena COVID-19 Working Group (MoCo19)Borghi VMattioli MBusani SBiagioni ECorradi LClini EFidanza LFranceschini ECiusa GGuaraldi GCorradini EFantini RBorella RScotti MColoretti IBrugioni LFaltoni MFranceschi GGaetano MDMoretti ABedini ATartaro DLCerbone CIannone AMeschiari MRomagnoli EYaacoub DCossarizza ARighini GCuomo GBurastero GCastaniere INani CGibellini LGirardis MCarli FCozzi-Lepri APaolini ATutone MOrlando GFogliani RSerio LGaetano ABacca EVermi MSantoro ABellinazzi CVolpi SPuzzolante CBiasi SPellegrino MRMilic JMussini CfalseFirst and second waves among hospitalised patients with COVID-19 with severe pneumonia: a comparison of 28-day mortality over the 1-year pandemic in a tertiary university hospital in Italy.<h4>Objective</h4>The first COVID-19-19 epidemic wave was over the period of February-May 2020. Since 1 October 2020, Italy, as many other European countries, faced a second wave. The aim of this analysis was to compare the 28-day mortality between the two waves among COVID-19 hospitalised patients.<h4>Design</h4>Observational cohort study. Standard survival analysis was performed to compare all-cause mortality within 28 days after hospital admission in the two waves. Kaplan-Meier curves as well as Cox regression model analysis were used. The effect of wave on risk of death was shown by means of HRs with 95% CIs. A sensitivity analysis around the impact of the circulating variant as a potential unmeasured confounder was performed.<h4>Setting</h4>University Hospital of Modena, Italy. Patien2022-01-01T00:00:00Z2022 Jan2025-05-31T22:37:57.946Z2025-05-31T22:37:57.946ZS-EPMC87245933498062310.1136/bmjopen-2021-054069