biostudies-literatureFurukawa TJapan Society for the Promotion of Sciencee002479https://www.ebi.ac.uk/biostudies/studies/S-EPMC8724736biostudies-literatureUnknown10(1)<h4>Introduction</h4>Healthy diet and physical activity (PA) are essential for preventing type 2 diabetes, particularly, a combination of diet and PA. However, reports on interaction between PA and diet, especially from large epidemiological studies, are limited. We investigated the effect of interaction between PA and macronutrient intake on hemoglobin A1c (HbA1c) levels in the general population.<h4>Research design and methods</h4>We conducted a cross-sectional study of 55 469 men and women without diabetes who participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. A self-administered questionnaire ascertained PA and macronutrient intake (carbohydrate, fat, and protein). Multiple linear regression analyses were performed to adjust for confoundingBMJ open diabetes research & careEffect of the interaction between physical activity and estimated macronutrient intake on HbA1c: population-based cross-sectional and longitudinal studies.PMC872473621K06645221S00011701501816H06277Nagase HWakai KJapan Multi-Institutional Collaborative Cohort (J-MICC) Study GroupMiura KSuzuki SMatsuo KKoga KNakagawa-Senda HTakezaki TIto HKusakabe MUehara RArisawa KHara MTanaka KHigaki YTamura TNarimatsu HKita YIbusuki RMikami HMatsui DKato YHishida AKadota ATakeuchi KShibuya KIwasaka CTamada YNakamura YShimanoe CFurukawa TKuriki KNakashima RKatsuura-Kamano SOzaki ENishida YIkezaki HfalseEffect of the interaction between physical activity and estimated macronutrient intake on HbA1c: population-based cross-sectional and longitudinal studies.<h4>Introduction</h4>Healthy diet and physical activity (PA) are essential for preventing type 2 diabetes, particularly, a combination of diet and PA. However, reports on interaction between PA and diet, especially from large epidemiological studies, are limited. We investigated the effect of interaction between PA and macronutrient intake on hemoglobin A1c (HbA1c) levels in the general population.<h4>Research design and methods</h4>We conducted a cross-sectional study of 55 469 men and women without diabetes who participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. A self-administered questionnaire ascertained PA and macronutrient intake (carbohydrate, fat, and protein). Multiple linear regression analyses were performed to adjust for confounding2022-01-01T00:00:00Z2022 Jan2026-07-16T15:09:15.673Z2026-07-09T11:03:02.321ZS-EPMC87247363498059210.1136/bmjdrc-2021-002479