{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bae JS"],"funding":["Ministry of Trade, Industry and Energy","Korea Health Industry Development Institute","National Research Foundation of Korea"],"pagination":["59-72"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8724832"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["<h4>Purpose</h4>Data on the effects of direct particulate matter (PM) exposure on the eyes and the nose are limited. Here, an interleukin (IL)-17/neutrophil-dominant ovalbumin (OVA)/polyinosinic-polycytidylic acid (Poly(I:C)) mouse model was used to evaluate the effect of different-sized titanium dioxide (TiO<sub>2</sub>) particles on the eyes and the nose. We also examined whether IL-17-neutralizing antibody (IL-17Ab) treatment could reverse TiO<sub>2</sub> effects.<h4>Methods</h4>The nasal cavities and conjunctival sacs of each mouse were challenged with OVA and Poly(I:C) to induce neutrophil-dominant inflammation and then exposed to micro- and nano-TiO<sub>2</sub>. Subsequently, IL-17Ab was administered to investigate the role of IL-17 and inflammatory parameters.<h4>Results</h4>Micro- "],"journal":["Allergy, asthma & immunology research"],"pubmed_title":["Particulate Matter Exposure Aggravates IL-17-Induced Eye and Nose Inflammation in an OVA/Poly(I:C) Mouse Model."],"pmcid":["PMC8724832"],"funding_grant_id":["20016884","2020R1A2C1012105","NRF-2018K1A4A3A02060572","NRF-2020R1A6A1A03043283","HI20C2088"],"pubmed_authors":["Kim EH","Cho KJ","Kim H","Bae JS","Kim JH","Kim J","Mo JH","Oh SB"],"additional_accession":[]},"is_claimable":false,"name":"Particulate Matter Exposure Aggravates IL-17-Induced Eye and Nose Inflammation in an OVA/Poly(I:C) Mouse Model.","description":"<h4>Purpose</h4>Data on the effects of direct particulate matter (PM) exposure on the eyes and the nose are limited. Here, an interleukin (IL)-17/neutrophil-dominant ovalbumin (OVA)/polyinosinic-polycytidylic acid (Poly(I:C)) mouse model was used to evaluate the effect of different-sized titanium dioxide (TiO<sub>2</sub>) particles on the eyes and the nose. We also examined whether IL-17-neutralizing antibody (IL-17Ab) treatment could reverse TiO<sub>2</sub> effects.<h4>Methods</h4>The nasal cavities and conjunctival sacs of each mouse were challenged with OVA and Poly(I:C) to induce neutrophil-dominant inflammation and then exposed to micro- and nano-TiO<sub>2</sub>. Subsequently, IL-17Ab was administered to investigate the role of IL-17 and inflammatory parameters.<h4>Results</h4>Micro- ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-06-01T00:06:30.837Z","creation":"2025-06-01T00:06:30.837Z"},"accession":"S-EPMC8724832","cross_references":{"pubmed":["34983107"],"doi":["10.4168/aair.2022.14.1.59"]}}