biostudies-literatureBae JSMinistry of Trade, Industry and EnergyKorea Health Industry Development InstituteNational Research Foundation of Korea59-72https://www.ebi.ac.uk/biostudies/studies/S-EPMC8724832biostudies-literatureUnknown14(1)<h4>Purpose</h4>Data on the effects of direct particulate matter (PM) exposure on the eyes and the nose are limited. Here, an interleukin (IL)-17/neutrophil-dominant ovalbumin (OVA)/polyinosinic-polycytidylic acid (Poly(I:C)) mouse model was used to evaluate the effect of different-sized titanium dioxide (TiO₂) particles on the eyes and the nose. We also examined whether IL-17-neutralizing antibody (IL-17Ab) treatment could reverse TiO₂ effects.<h4>Methods</h4>The nasal cavities and conjunctival sacs of each mouse were challenged with OVA and Poly(I:C) to induce neutrophil-dominant inflammation and then exposed to micro- and nano-TiO₂. Subsequently, IL-17Ab was administered to investigate the role of IL-17 and inflammatory parameters.<h4>Results</h4>Micro- Allergy, asthma & immunology researchParticulate Matter Exposure Aggravates IL-17-Induced Eye and Nose Inflammation in an OVA/Poly(I:C) Mouse Model.PMC8724832200168842020R1A2C1012105NRF-2018K1A4A3A02060572NRF-2020R1A6A1A03043283HI20C2088Kim EHCho KJKim HBae JSKim JHKim JMo JHOh SBfalseParticulate Matter Exposure Aggravates IL-17-Induced Eye and Nose Inflammation in an OVA/Poly(I:C) Mouse Model.<h4>Purpose</h4>Data on the effects of direct particulate matter (PM) exposure on the eyes and the nose are limited. Here, an interleukin (IL)-17/neutrophil-dominant ovalbumin (OVA)/polyinosinic-polycytidylic acid (Poly(I:C)) mouse model was used to evaluate the effect of different-sized titanium dioxide (TiO₂) particles on the eyes and the nose. We also examined whether IL-17-neutralizing antibody (IL-17Ab) treatment could reverse TiO₂ effects.<h4>Methods</h4>The nasal cavities and conjunctival sacs of each mouse were challenged with OVA and Poly(I:C) to induce neutrophil-dominant inflammation and then exposed to micro- and nano-TiO₂. Subsequently, IL-17Ab was administered to investigate the role of IL-17 and inflammatory parameters.<h4>Results</h4>Micro- 2022-01-01T00:00:00Z2022 Jan2025-06-01T00:06:30.837Z2025-06-01T00:06:30.837ZS-EPMC87248323498310710.4168/aair.2022.14.1.59