{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Navarro E"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke","NIA NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Aging","NINDS NIH HHS","NIH HHS"],"pagination":["850-863"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8728893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1(9)"],"pubmed_abstract":["An increasing number of identified Parkinson's disease (PD) risk loci contain genes highly expressed in innate immune cells, yet their role in pathology is not understood. We hypothesize that PD susceptibility genes modulate disease risk by influencing gene expression within immune cells. To address this, we have generated transcriptomic profiles of monocytes from 230 individuals with sporadic PD and healthy subjects. We observed a dysregulation of mitochondrial and proteasomal pathways. We also generated transcriptomic profiles of primary microglia from brains of 55 subjects and observed discordant transcriptomic signatures of mitochondrial genes in PD monocytes and microglia. We further identified 17 PD susceptibility genes whose expression, relative to each risk allele, is altered in mo"],"journal":["Nature aging"],"pubmed_title":["Dysregulation of mitochondrial and proteolysosomal genes in Parkinson's disease myeloid cells."],"pmcid":["PMC8728893"],"funding_grant_id":["P50 AG005138","F32 AG056098","U01 NS094148","S10 OD026880","U01-NS107016","S10 OD018522","R21-AG063130","R01 AG054005","R01-AG054005","R01-NS116006","R21 AG063130","U01 NS107016","U01 NS120256","R01 NS116006","U01-NS094148"],"pubmed_authors":["Riboldi G","Swan M","Shanker V","Lopes KP","Sikder T","Tse W","Ramdhani R","Farrell K","Snijders GJL","Humphrey J","Zhu CW","Walker RH","Bressman S","Simon S","Saunders-Pullman R","Raymond D","Elango S","de Witte L","Frucht S","Navarro E","Pereira AC","Goate AM","Raj T","Zhuang M","Argyrou C","Udine E","Parks M","Chao MJ","Ortega RA","Schilder BM","Allan A","Sano M","Vialle RA","Ahfeldt T","Crary JF","Henderson B"],"additional_accession":[]},"is_claimable":false,"name":"Dysregulation of mitochondrial and proteolysosomal genes in Parkinson's disease myeloid cells.","description":"An increasing number of identified Parkinson's disease (PD) risk loci contain genes highly expressed in innate immune cells, yet their role in pathology is not understood. We hypothesize that PD susceptibility genes modulate disease risk by influencing gene expression within immune cells. To address this, we have generated transcriptomic profiles of monocytes from 230 individuals with sporadic PD and healthy subjects. We observed a dysregulation of mitochondrial and proteasomal pathways. We also generated transcriptomic profiles of primary microglia from brains of 55 subjects and observed discordant transcriptomic signatures of mitochondrial genes in PD monocytes and microglia. We further identified 17 PD susceptibility genes whose expression, relative to each risk allele, is altered in mo","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-05-31T08:58:28.986Z","creation":"2024-11-12T06:29:34.006Z"},"accession":"S-EPMC8728893","cross_references":{"pubmed":["35005630"],"doi":["10.1038/s43587-021-00110-x"]}}