{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pleshinger MJ"],"funding":["Edward Mallinckrodt, Jr. Foundation","NCATS NIH HHS","Mt. Sinai Health Care Foundation","Case Comprehensive Cancer Center, Case Western Reserve University","G. Harold and Leila Y. Mathers Foundation","Case Western Reserve University","NINDS NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["56-68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8729178"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(1)"],"pubmed_abstract":["While the cholesterol biosynthesis pathway has been extensively studied, recent work has forged new links between inhibition of specific sterol pathway enzymes, accumulation of their unique sterol substrates, and biological areas as diverse as cancer, immunology, and neurodegenerative disease. We recently reported that dozens of small molecules enhance formation of oligodendrocytes, a glial cell type lost in multiple sclerosis, by inhibiting CYP51, Sterol 14-reductase, or EBP and inducing cellular accumulation of their 8,9-unsaturated sterol substrates. Several adjacent pathway enzymes also have 8,9-unsaturated sterol substrates but have not yet been evaluated as potential targets for oligodendrocyte formation or in many other biological contexts, in part due to a lack of available small-m"],"journal":["RSC chemical biology"],"pubmed_title":["Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation."],"pmcid":["PMC8729178"],"funding_grant_id":["T32 GM007250","R35 NS116842","2R25GM075207-14","F30MH116581","T32GM008803","P30CA043703","T32 GM008803","TL1TR000441","TL1 TR002549"],"pubmed_authors":["Rivera-Leon AM","Pleshinger MJ","Hubler Z","Adams DJ","Bederman I","Friedrich RM","Tesar PJ","Sax JL","Srinivasan R","Yan D","Shick HE","Gao F"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of SC4MOL and HSD17B7 shifts cellular sterol composition and promotes oligodendrocyte formation.","description":"While the cholesterol biosynthesis pathway has been extensively studied, recent work has forged new links between inhibition of specific sterol pathway enzymes, accumulation of their unique sterol substrates, and biological areas as diverse as cancer, immunology, and neurodegenerative disease. We recently reported that dozens of small molecules enhance formation of oligodendrocytes, a glial cell type lost in multiple sclerosis, by inhibiting CYP51, Sterol 14-reductase, or EBP and inducing cellular accumulation of their 8,9-unsaturated sterol substrates. Several adjacent pathway enzymes also have 8,9-unsaturated sterol substrates but have not yet been evaluated as potential targets for oligodendrocyte formation or in many other biological contexts, in part due to a lack of available small-m","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-04T08:57:03.47Z","creation":"2024-10-18T17:10:23.317Z"},"accession":"S-EPMC8729178","cross_references":{"pubmed":["35128409"],"doi":["10.1039/d1cb00145k"]}}