{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Graham SE"],"funding":["Economic and Social Research Council","BLRD VA","Cancer Research UK","British Heart Foundation","NICHD NIH HHS","NCCDPHP CDC HHS","NIA NIH HHS","NHLBI NIH HHS","Public Health Agency","NNF Center for Basic Metabolic Research","Lundbeck Foundation","CSRD VA","NIDDK NIH HHS","Barts Charity","Medical Research Council","National Institute for Health Research (NIHR)","NHGRI NIH HHS","Novo Nordisk Fonden","Wellcome Trust"],"pagination":["675-679"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8730582"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["600(7890)"],"pubmed_abstract":["Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use<sup>1</sup>. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels<sup>2</sup>, heart disease remains the leading cause of death worldwide<sup>3</sup>. Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS<sup>4-23</sup> have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid-level variation in other ancestry groups. These include differences in allele fre"],"journal":["Nature"],"pubmed_title":["The power of genetic diversity in genome-wide association studies of lipids."],"pmcid":["PMC8730582"],"funding_grant_id":["R01 HD030880","R01 HL149683","MR/S011676/1","NNF13OC0005785","R01 HL133218","MC_UU_12026/2","ES/L008459/1","I01 BX004821","G9521010","MR/R024227/1","P30 DK020572","NNF14OC0010513","T32 HG000040","R01 HL109946","MC_PC_15018","MC_U137686851","Hansen Group","K01 HL135405","MC_UU_00007/10","212946/Z/18/Z","P30 AG010161","NF-SI-0617-10154","U01 HG011723","U01 DP006266","Pedersen Group","16/136/102","I01 BX003362","NF-SI-0512-10113","R01 DK072193","NNF19OC0055250","MC_PC_19009","R01 AG015819","U19 AG063893","STL/5569/19","U01 DK062370","NIHR-INF-0987","221854/Z/20/Z","R01 HG010297","MC_PC_20026","R03 HL154284","R01 HL153805","R01 DK093757","MR/S019669/1","NF-SI-0611-10170","Grarup Group","217065/Z/19/Z","MGU0284","202802/Z/16/Z","16896","R35 HL135824","MC_UU_00017/1","RG/14/5/30893","G9815508","K08 HG010155","MC_PC_14135","R01 HL127564","IK2 CX001780","NNF18OC0033898","212945/Z/18/Z","R155-2013-14070","210561/Z/18/Z","Phenomics","R35 HL135818","FS/19/62/34901D","ES/N00812X/1","R01 DK062370","P30 DK020541","R01 AG017917","MC_PC_13049","R01 HL105756","MC_UU_00006/1"],"pubmed_authors":["Hildalgo B","Neville MJ","Ramdas S","Pitsillides A","Kawaguchi T","Asselbergs FW","Verweij N","Zhao JH","Matsuda F","Kleber ME","Tonjes A","Clarke SL","Couture C","Kamatani Y","Ramirez J","Walker M","Weir DR","Kathiresan S","Locke AE","Ciullo M","Raitakari OT","Caulfield MJ","Ritchie MD","Warner SC","Chaturvedi N","Zajac GJM","Wickremasinghe AR","Scott RJ","Penninx B","Bollepalli S","Preuss M","Wang YX","Thorsteinsdottir U","Feng Q","Vaccargiu S","Jackson AU","Heid IM","Concas MP","Gordon-Larsen P","Ripatti S","Yu K","Munroe PB","Terzikhan N","Bharadwaj D","Global Lipids Genetics Consortium*","Olafsson I","Wong A","Reilly DF","Yajnik CS","Chai X","Rasheed A","Ridker PM","Sakaue S","Wielscher M","Rasheed H","Dedoussis G","van Dam RM","Smith BH","Klarin D","Brumpton BM","Mitchell RE","Kuusisto J","Faul JD","Haworth S","Oldmeadow C","Jousilahti P","Zhu X","Koistinen HA","Mohlke KL","Turman C","Loukola A","Ho YL","Tamiya G","Bradford Y","Wilson JF","Wilson JG","Karhus LL","Chen Z","Orozco L","Lamina C","Theusch E","Kurbasic A","Chen S","Marques-Vidal P","Gieger C","Kentistou KA","Kahonen M","Yoon K","Jarvelin MR","Fiorillo E","Mamakou V","Holmes MV","Huo S","Christensen H","Liu J","Marz W","Poulter N","Jockel KH","Fernandez-Lopez JC","Kivimaki M","Christofidou P","Winkler TW","Lettre G","Lind L","Pasterkamp G","Weiss S","Arnett DK","Rosenthal EA","Elders PJM","De Jager PL","Scholz M","Abbas S","Pedersen O","Homuth G","O'Donnell CJ","Graham SE","Snieder H","Giardoglou T","Zimmermann ME","Hansen T","Delgado GE","Stark KJ","Ikeda DD","Launer LJ","Liu F","Zmuda JM","Hayes MG","Volzke H","Guo X","Biino G","Thuesen BH","Ahmed M","Highland HM","Chasman DI","Rallidis LS","Villalpando CG","Warren HR","Baras A","Damrauer SM","Brown CD","McDaid AF","Tardif JC","Frayling TM","Sung YJ","Rotimi CN","Obura MO","Perusse L","Magnusson PKE","Niinikoski H","Noordam R","Pendergrass SA","Laakso M","Arendt M","Nalls MA","Wu KH","Christensen K","Qu J","Hebbar P","Graff M","Franke A","Sabater-Lleal M","Han S","Wu JY","Schulze MB","Deloukas P","Mori TA","Chitrala KN","Wareham NJ","Kanoni S","Southam L","Yuan JM","Ruotsalainen SE","Reiner AP","Lo KS","Hewitt AW","Mitchell P","Cuellar-Partida G","Black C","Khera AV","Bennett DA","Kooperberg C","Grarup N","Ruggiero D","Wang CA","Asvold BO","de Vries PS","Palmer CNA","Lyssenko V","Schmidt B","VA Million Veteran Program","Grant SFA","Haessler J","Chai JF","Spracklen CN","Schmidt H","Gu D","Pandit A","Schmidt R","Marten J","McKnight AJ","Schunkert H","Pacheco JA","Yao J","Trivedi B","Rhee SY","'t Hart LM","Manichaikul A","Kember RL","Slieker RC","Gao Z","Hazelhurst S","Lange LA","Hwang MY","Wild SH","Kutalik Z","van der Most PJ","de Kleijn D","Ramsay M","Willer CJ","Hofer E","Ingelsson E","Lores-Motta L","de Geus EJC","Fuchsberger C","Tabara Y","Cho K","Sun YV","Pramstaller PP","Smyth LJ","Lin SY","Kim HL","van der Harst P","Galesloot TE","Kim HN","Kovacs P","Shu XO","Rao DC","Vitart V","Miller JE","Chambers JC","Cade BE","Whitfield JB","Jonas JB","Ji Y","Aadahl M","Benjamins JW","Bork-Jensen J","Kumari M","North KE","Cupples LA","Psaty BM","Kardia SLR","Kaprio J","Martin NG","Xue C","Jukema JW","Lin X","Terao C","Luan J","van Dijk KW","Lynch JA","Hui Q","Trembath RC","de Silva HJ","Zeng L","Buring JE","Poveda A","Girotto G","Huerta-Chagoya A","Justice AE","Watkins H","Lyytikainen LP","Cho YS","Yousri NA","van Heel DA","Holm H","Zeggini E","Lin K","Jackson RD","Lin M","Boger CA","Kim EK","Hindy G","Giulianini F","Kiemeney LALM","Millwood IY","Hunt KA","Zhao W","van Meurs JBJ","Katsuya T","Sever P","Loos RJF","Brown MR","Timpson NJ","Nikus K","Daviglus M","Jarvik GP","Widen E","Choudhury A","Nadkarni GN","Nakatochi M","van Setten J","Heng CK","Wang JS","Martin LW","Rayner NW","Bis JC","Boehnke M","Vestergaard H","Cruz M","Havulinna AS","Jager S","Mellstrom D","Gorski M","Peters A","Rotter JI","Thorleifsson G","Kronenberg F","Pennell CE","Daw EW","Verma A","Sabanayagam C","Takeuchi F","Iha H","Li H","Abecasis G","Tsao PS","Willemsen G","Walters RG","Xia R","Kim BJ","Li L","van Duijn CM","Li X","Pahkala K","Samani NJ","Hakonarson H","Assimes TL","Giannakopoulou O","Fornage M","Mercader JM","Brumat M","Nethander M","Cai Q","Ichihara S","Parra EJ","den Hollander AI","Munz M","Feitosa MF","Mannikko M","Shin JH","Mangino M","Namjou B","Chandak GR","Natarajan P","Loeffler M","Morris AP","Yin X","Hottenga JJ","Kooner JS","Murakami Y","Engmann J","Helgadottir A","de Borst GJ","Tusie-Luna T","Hoefer IE","Zhang W","Hirschhorn JN","Ntalla I","Gudbjartsson DF","Mollehave LT","Saleheen D","Gaziano JM","Trompet S","McCarthy MI","Wilson P","Province MA","Zhang J","Chen YE","Pajukanta P","Gudnason V","Bielak LF","Tai ES","Morrison AC","Mahajan A","Simonsick E","Forer L","Lieb W","Chang KM","Akiyama M","Ikram MA","Mook-Kanamori DO","Oldehinkel AJ","Ryu S","Hayward C","Cucca F","Dantoft TM","Zheng W","Nelson CP","Redline S","van der Laan SW","Meidtner K","Hattersley AT","Schwander K","Kanai M","Adams HHH","Wojczynski MK","Thiery J","Franks PW","Irvin MR","Dorajoo R","Erdmann J","Zilhao NR","Lee J","Salomaa V","Correa A","Lee H","Sattar N","Veturi Y","Koh WP","Woo JT","Pedersen NL","Bouchard C","Al-Mulla F","Khor CC","Smith JA","Kubo M","Krauss RM","Ekoru K","Surakka I","Goel A","Brandslund I","Boomsma DI","Nabika T","Zhou W","Lingren T","Jung B","Bradfield JP","Lee JY","Hung YJ","Aguilar-Salinas CA","Yokota M","Hunt SC","Huang W","Nelson AE","Marouli E","Medina-Gomez C","Leonard HL","Golightly YM","Braund PS","Jang HM","Huang J","Mitchell JS","Kolcic I","Lu X","Stefansson K","Wang C","Huang H","Young KL","Ohlsson C","Bhatti KF","Thanaraj TA","Schmidt EM","Zonderman AB","Hveem K","Vedantam S","Wood AR","Spector TD","Gustafsson S","Peloso GM","de Graaf J","Pauper M","Joshi PK","Pitkanen N","Yang J","Yamamoto M","Freitag-Wolf S","Hutri-Kahonen N","Choi HS","Yang B","Lu F","Le P","Evans MK","Cheng CY","Wong TY","Prasad G","Brody JA","Attia J","Kraft P","Canadas-Garre M","Adair LS","Arbeeva L","Kee F","Rader DJ","Linneberg A","Polasek O","Narita A","Long J","Nutile T","Beulens JWJ","Bentley AR","Farmaki AE","Bandinelli S","Bechayda SA","Kato N","Kim YJ","Lehtimaki T","Karpe F","Ghanbari M","Wei WB","Kraaijeveld AO","Strachan DP","Wei WQ","Sim X","Langenberg C","Timmers PRHJ","Campbell H","Sidore C","Okada Y","Brown M","Hishigaki H","Campbell A","Chen YI","Martin HC"],"additional_accession":[]},"is_claimable":false,"name":"The power of genetic diversity in genome-wide association studies of lipids.","description":"Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use<sup>1</sup>. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels<sup>2</sup>, heart disease remains the leading cause of death worldwide<sup>3</sup>. Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS<sup>4-23</sup> have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid-level variation in other ancestry groups. These include differences in allele fre","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2026-05-29T14:56:36.303Z","creation":"2025-04-04T20:16:08.751Z"},"accession":"S-EPMC8730582","cross_references":{"pubmed":["34887591"],"doi":["10.1038/s41586-021-04064-3"]}}