{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Carvalho CCCR"],"funding":["Research Unit iBB-Institute for Bioengineering and Biosciences","FCT in the scope","NIAID NIH HHS","Fundação para a Ciência e a Tecnologia, I.P. (FCT, Portugal) through programme ‘Investigador FCT 2013’","National Institutes of Health","NIH HHS"],"pagination":["135-147"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8730685"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77(1)"],"pubmed_abstract":["<h4>Background</h4>The cyclic anionic lipopeptide daptomycin is used in the treatment of severe infections caused by Gram-positive pathogens, including MRSA. Daptomycin resistance, although rare, often results in treatment failure. Paradoxically, in MRSA, daptomycin resistance is usually accompanied by a concomitant decrease in β-lactam resistance in what is known as the 'see-saw effect'. This resensitization is extensively used for the treatment of MRSA infections, by combining daptomycin and a β-lactam antibiotic, such as oxacillin.<h4>Objectives</h4>We aimed: (i) to investigate the combined effects of daptomycin and oxacillin on the lipid composition of the cellular membrane of both daptomycin-resistant and -susceptible MRSA strains; and (ii) to assess the involvement of the post-transl"],"journal":["The Journal of antimicrobial chemotherapy"],"pubmed_title":["Impact of PrsA on membrane lipid composition during daptomycin-resistance-mediated β-lactam sensitization in clinical MRSA strains."],"pmcid":["PMC8730685"],"funding_grant_id":["NIH-R56AI102503-01A1","UIDB/04565/2020","R56 AI102503","IF/01203/ 2013/CP1163/CT0002","UIDP/04565/2020"],"pubmed_authors":["Taglialegna A","Rosato AE","de Carvalho CCCR"],"additional_accession":[]},"is_claimable":false,"name":"Impact of PrsA on membrane lipid composition during daptomycin-resistance-mediated β-lactam sensitization in clinical MRSA strains.","description":"<h4>Background</h4>The cyclic anionic lipopeptide daptomycin is used in the treatment of severe infections caused by Gram-positive pathogens, including MRSA. Daptomycin resistance, although rare, often results in treatment failure. Paradoxically, in MRSA, daptomycin resistance is usually accompanied by a concomitant decrease in β-lactam resistance in what is known as the 'see-saw effect'. This resensitization is extensively used for the treatment of MRSA infections, by combining daptomycin and a β-lactam antibiotic, such as oxacillin.<h4>Objectives</h4>We aimed: (i) to investigate the combined effects of daptomycin and oxacillin on the lipid composition of the cellular membrane of both daptomycin-resistant and -susceptible MRSA strains; and (ii) to assess the involvement of the post-transl","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-19T17:37:16.04Z","creation":"2025-04-19T17:37:16.04Z"},"accession":"S-EPMC8730685","cross_references":{"pubmed":["34618036"],"doi":["10.1093/jac/dkab356"]}}