biostudies-literatureUnknown9Tesovnik TTogether with metabolites, proteins, and lipid components, the EV cargo consists of DNA and RNA nucleotide sequence species, which are part of the intracellular communication network regulating specific cellular processes and provoking distinct target cell responses. The extracellular vesicle (EV) nucleotide sequence cargo molecules are often investigated in association with a particular pathology and may provide an insight into the physiological and pathological processes in hard-to-access organs and tissues. The diversity and biological function of EV nucleotide sequences are distinct regarding EV subgroups and differ in tissue- and cell-released EVs. EV DNA is present mainly in apoptotic bodies, while there are different species of EV RNAs in all subgroups of EVs. A limited sample volumFrontiers in bioengineering and biotechnology787551https://www.ebi.ac.uk/biostudies/studies/S-EPMC8733665biostudies-literatureTechnological Approaches in the Analysis of Extracellular Vesicle Nucleotide Sequences.PMC8733665Debeljak MJenko Bizjan BTesovnik TKovac JBattelino TSket RfalseTechnological Approaches in the Analysis of Extracellular Vesicle Nucleotide Sequences.Together with metabolites, proteins, and lipid components, the EV cargo consists of DNA and RNA nucleotide sequence species, which are part of the intracellular communication network regulating specific cellular processes and provoking distinct target cell responses. The extracellular vesicle (EV) nucleotide sequence cargo molecules are often investigated in association with a particular pathology and may provide an insight into the physiological and pathological processes in hard-to-access organs and tissues. The diversity and biological function of EV nucleotide sequences are distinct regarding EV subgroups and differ in tissue- and cell-released EVs. EV DNA is present mainly in apoptotic bodies, while there are different species of EV RNAs in all subgroups of EVs. A limited sample volum2021-01-01T00:00:00Z20212025-04-26T15:43:03.912Z2022-02-11T15:11:37.217ZS-EPMC87336653500464710.3389/fbioe.2021.787551