biostudies-literatureFolgado EEuropean Research CouncilCentre National de la Recherche ScientifiqueRoyal Society4235-4243https://www.ebi.ac.uk/biostudies/studies/S-EPMC8734003biostudies-literatureUnknown12(29)The synthesis of cyclic peptide-poly(vinylidene fluoride) (CP-PVDF) conjugates comprising (d-<i>alt</i>-l)-cyclopeptides as building blocks and their self-assembly into tube-like structures is described. By growing two PVDF polymeric chains from opposite sides of a preassembled cyclic-peptide macro-chain transfer agent, a PVDF-CP-PVDF conjugate was prepared. This "grafting-from" strategy, allowed the synthesis of the conjugate with high purity and using facile purification steps. The controlled self-assembly of the conjugate from DMF or DMSO solutions was carried out by addition of THF. This triggered the aggregation process that led to formation of tube-like structures. The mean length and width of the PVDF-CP-PVDF tubes were measured using atomic force microscopy (AFM) and transmission ePolymer chemistryFluorinated nanotubes: synthesis and self-assembly of cyclic peptide-poly(vinylidene fluoride) conjugates.PMC8734003647106IE161841Ladmiral VSemsarilar MSong QPerrier SFolgado EfalseFluorinated nanotubes: synthesis and self-assembly of cyclic peptide-poly(vinylidene fluoride) conjugates.The synthesis of cyclic peptide-poly(vinylidene fluoride) (CP-PVDF) conjugates comprising (d-<i>alt</i>-l)-cyclopeptides as building blocks and their self-assembly into tube-like structures is described. By growing two PVDF polymeric chains from opposite sides of a preassembled cyclic-peptide macro-chain transfer agent, a PVDF-CP-PVDF conjugate was prepared. This "grafting-from" strategy, allowed the synthesis of the conjugate with high purity and using facile purification steps. The controlled self-assembly of the conjugate from DMF or DMSO solutions was carried out by addition of THF. This triggered the aggregation process that led to formation of tube-like structures. The mean length and width of the PVDF-CP-PVDF tubes were measured using atomic force microscopy (AFM) and transmission e2021-01-01T00:00:00Z2021 Jul2025-05-29T16:07:03.271Z2025-05-29T16:07:03.271ZS-EPMC87340033512668510.1039/d1py00355k