{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kumar R"],"funding":["National Heart, Lung, and Blood Institute","NHLBI NIH HHS"],"pagination":["25813-25824"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8735666"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(22)"],"pubmed_abstract":["Antimicrobial-lock therapy is an economically viable strategy to prevent/reduce the catheter-related bloodstream infections (CRBSI) that are associated with central venous catheters (CVCs). Herein, we report the synthesis and characterization of the <i>S</i>-nitroso-<i>N</i>-acetyl-l-cysteine ethyl ester (SNACET), a nitric oxide (NO)-releasing molecule, and for the first time its application as a catheter lock solution to combat issues of bacterial infection associated with indwelling catheters. Nitric oxide is an endogenous gasotransmitter that exhibits a wide range of biological properties, including broad-spectrum antimicrobial activity. The storage stability of the SNACET and the NO release behavior of the prepared lock solution were analyzed. SNACET lock solutions with varying concent"],"journal":["ACS applied materials & interfaces"],"pubmed_title":["<i>S</i>-Nitroso-<i>N</i>-acetyl-l-cysteine Ethyl Ester (SNACET) Catheter Lock Solution to Reduce Catheter-Associated Infections."],"pmcid":["PMC8735666"],"funding_grant_id":["R01 HL151473","R01HL151473"],"pubmed_authors":["Massoumi H","Brisbois EJ","Kumar R","Chug MK"],"additional_accession":[]},"is_claimable":false,"name":"<i>S</i>-Nitroso-<i>N</i>-acetyl-l-cysteine Ethyl Ester (SNACET) Catheter Lock Solution to Reduce Catheter-Associated Infections.","description":"Antimicrobial-lock therapy is an economically viable strategy to prevent/reduce the catheter-related bloodstream infections (CRBSI) that are associated with central venous catheters (CVCs). Herein, we report the synthesis and characterization of the <i>S</i>-nitroso-<i>N</i>-acetyl-l-cysteine ethyl ester (SNACET), a nitric oxide (NO)-releasing molecule, and for the first time its application as a catheter lock solution to combat issues of bacterial infection associated with indwelling catheters. Nitric oxide is an endogenous gasotransmitter that exhibits a wide range of biological properties, including broad-spectrum antimicrobial activity. The storage stability of the SNACET and the NO release behavior of the prepared lock solution were analyzed. SNACET lock solutions with varying concent","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-04T07:48:01.009Z","creation":"2025-04-04T07:48:01.009Z"},"accession":"S-EPMC8735666","cross_references":{"pubmed":["34029456"],"doi":["10.1021/acsami.1c06427"]}}