{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Spinello BJ"],"funding":["Welch Foundation","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["13507-13512"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8739284"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["143(34)"],"pubmed_abstract":["The first examples of rhodium-catalyzed carbonyl addition via hydrogen autotransfer are described, as illustrated in tandem butadiene-mediated carbonyl addition-redox isomerizations that directly convert primary alcohols to isobutyl ketones. Related reductive coupling-redox isomerizations of aldehyde reactants mediated by sodium formate also are reported. A double-labeling crossover experiment reveals that the rhodium alkoxide obtained upon carbonyl addition enacts redox isomerization without dissociation of rhodium at any intervening stage."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Conversion of Primary Alcohols and Butadiene to Branched Ketones via Merged Transfer Hydrogenative Carbonyl Addition-Redox Isomerization Catalyzed by Rhodium."],"pmcid":["PMC8739284"],"funding_grant_id":["R01 GM069445","RO1-GM069445","F-0038"],"pubmed_authors":["Wu J","Cho Y","Spinello BJ","Krische MJ"],"additional_accession":[]},"is_claimable":false,"name":"Conversion of Primary Alcohols and Butadiene to Branched Ketones via Merged Transfer Hydrogenative Carbonyl Addition-Redox Isomerization Catalyzed by Rhodium.","description":"The first examples of rhodium-catalyzed carbonyl addition via hydrogen autotransfer are described, as illustrated in tandem butadiene-mediated carbonyl addition-redox isomerizations that directly convert primary alcohols to isobutyl ketones. Related reductive coupling-redox isomerizations of aldehyde reactants mediated by sodium formate also are reported. A double-labeling crossover experiment reveals that the rhodium alkoxide obtained upon carbonyl addition enacts redox isomerization without dissociation of rhodium at any intervening stage.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2024-11-10T06:25:52.268Z","creation":"2024-11-10T06:25:52.268Z"},"accession":"S-EPMC8739284","cross_references":{"pubmed":["34415159"],"doi":["10.1021/jacs.1c07230"]}}