{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye J"],"funding":["Natural Science Foundation of Zhejiang Province"],"pagination":["778500"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8739481"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["<b>Background:</b> Biliary atresia (BA) is considered to be an autoimmune-mediating inflammatory injury. The pathogenesis of BA has been proposed with the clonal transformation of T cells expressing analogous T-cell receptor β-chain variable regions (TRBVs). <b>Methods:</b> The TRBV profile of the peripheral blood mononuclear cells (PBMCs) in infants with BA and control infants (healthy donors, HDs), respectively, were characterized by using high-throughput sequencing (HTS). The diversity of T cells was analyzed based on the frequency of complementarity-determining region 3 (CDR3) or V(CDR3)J. Moreover, the correlation between absolute lymphocyte count (ALC) and lactate dehydrogenase (LDH) or diversity (clonality) indices, respectively, were analyzed for subjects with BA and HD. <b>Results"],"journal":["Frontiers in medicine"],"pubmed_title":["Altered T-Cell Receptor β-Chain and Lactate Dehydrogenase Are Associated With the Immune Pathogenesis of Biliary Atresia."],"pmcid":["PMC8739481"],"funding_grant_id":["LY19H190004"],"pubmed_authors":["Tan L","Yang J","Shu Q","Lai D","Cao D","Hu L","Ye J","Zha H"],"additional_accession":[]},"is_claimable":false,"name":"Altered T-Cell Receptor β-Chain and Lactate Dehydrogenase Are Associated With the Immune Pathogenesis of Biliary Atresia.","description":"<b>Background:</b> Biliary atresia (BA) is considered to be an autoimmune-mediating inflammatory injury. The pathogenesis of BA has been proposed with the clonal transformation of T cells expressing analogous T-cell receptor β-chain variable regions (TRBVs). <b>Methods:</b> The TRBV profile of the peripheral blood mononuclear cells (PBMCs) in infants with BA and control infants (healthy donors, HDs), respectively, were characterized by using high-throughput sequencing (HTS). The diversity of T cells was analyzed based on the frequency of complementarity-determining region 3 (CDR3) or V(CDR3)J. Moreover, the correlation between absolute lymphocyte count (ALC) and lactate dehydrogenase (LDH) or diversity (clonality) indices, respectively, were analyzed for subjects with BA and HD. <b>Results","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-08T05:32:13.752Z","creation":"2022-02-11T15:05:59.58Z"},"accession":"S-EPMC8739481","cross_references":{"pubmed":["35004747"],"doi":["10.3389/fmed.2021.778500"]}}