{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Suzuki K"],"funding":["Academic Society for Research in Otolaryngology, Kansai Medical University"],"pubmed_abstract":["Background
Secretory carcinoma (SC) of the salivary gland is a recently described malignant tumor harboring characteristic ETV6-NTRK3 gene fusion. SC generally has a favorable clinical course, and is currently regarded as a low-grade carcinoma. However, a small subset of SCs demonstrates aggressive clinical features with histologically high-grade transformed morphology, the molecular pathogenesis of which has not yet been elucidated. In this study, we performed a clinicopathological and molecular genetic study of patients with SC of the head and neck displaying various clinical characteristics to investigate the differences of pathological and molecular genetics between low-grade and high-grade components of SC.Case presentation
Three cases with SC of the head and neck, inc"],"journal":["BMC medical genomics"],"pagination":["6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8739673"],"repository":["biostudies-literature"],"pubmed_title":["Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report."],"pmcid":["PMC8739673"],"pubmed_authors":["Kanda A","Harada H","Takeda M","Iwai H","Ohe C","Kawahara A","Suzuki K","Sawada S","Uemura Y","Sengupta B"],"additional_accession":[]},"is_claimable":false,"name":"Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report.","description":"Background
Secretory carcinoma (SC) of the salivary gland is a recently described malignant tumor harboring characteristic ETV6-NTRK3 gene fusion. SC generally has a favorable clinical course, and is currently regarded as a low-grade carcinoma. However, a small subset of SCs demonstrates aggressive clinical features with histologically high-grade transformed morphology, the molecular pathogenesis of which has not yet been elucidated. In this study, we performed a clinicopathological and molecular genetic study of patients with SC of the head and neck displaying various clinical characteristics to investigate the differences of pathological and molecular genetics between low-grade and high-grade components of SC.Case presentation
Three cases with SC of the head and neck, inc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-05-31T22:24:54.566Z","creation":"2025-05-31T22:24:54.566Z"},"accession":"S-EPMC8739673","cross_references":{"pubmed":["34991563"],"doi":["10.1186/s12920-022-01155-6"]}}