biostudies-literatureUnknown15(1)Suzuki KAcademic Society for Research in Otolaryngology, Kansai Medical University<h4>Background</h4>Secretory carcinoma (SC) of the salivary gland is a recently described malignant tumor harboring characteristic ETV6-NTRK3 gene fusion. SC generally has a favorable clinical course, and is currently regarded as a low-grade carcinoma. However, a small subset of SCs demonstrates aggressive clinical features with histologically high-grade transformed morphology, the molecular pathogenesis of which has not yet been elucidated. In this study, we performed a clinicopathological and molecular genetic study of patients with SC of the head and neck displaying various clinical characteristics to investigate the differences of pathological and molecular genetics between low-grade and high-grade components of SC.<h4>Case presentation</h4>Three cases with SC of the head and neck, incBMC medical genomics6https://www.ebi.ac.uk/biostudies/studies/S-EPMC8739673biostudies-literatureClinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report.PMC8739673Kanda AHarada HTakeda MIwai HOhe CKawahara ASuzuki KSawada SUemura YSengupta BfalseClinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report.<h4>Background</h4>Secretory carcinoma (SC) of the salivary gland is a recently described malignant tumor harboring characteristic ETV6-NTRK3 gene fusion. SC generally has a favorable clinical course, and is currently regarded as a low-grade carcinoma. However, a small subset of SCs demonstrates aggressive clinical features with histologically high-grade transformed morphology, the molecular pathogenesis of which has not yet been elucidated. In this study, we performed a clinicopathological and molecular genetic study of patients with SC of the head and neck displaying various clinical characteristics to investigate the differences of pathological and molecular genetics between low-grade and high-grade components of SC.<h4>Case presentation</h4>Three cases with SC of the head and neck, inc2022-01-01T00:00:00Z2022 Jan2025-05-31T22:24:54.566Z2025-05-31T22:24:54.566ZS-EPMC87396733499156310.1186/s12920-022-01155-6