{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(3-4)"],"submitter":["Coombes BJ"],"pubmed_abstract":["Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (<i>N</i> = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using <i>lassosum</i> and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; <i>p</i> value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; <i>p</i> value = 0.005)"],"journal":["Complex psychiatry"],"pagination":["80-89"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8740189"],"repository":["biostudies-literature"],"pubmed_title":["Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study."],"pmcid":["PMC8740189"],"pubmed_authors":["McCarthy MJ","Ozaki N","Cichon S","Baune BT","Garnham JS","Ferensztajn-Rochowiak E","Mitjans M","Nievergelt CM","Vieta E","Kahn JP","Bauer M","Akiyama K","Chen HC","Jamain S","Zandi PP","Squassina A","Leboyer M","Cervantes P","Kusumi I","Chillotti C","Simhandl C","Backlund L","Papiol S","Mitchell PB","Novak T","Hauser J","Colom F","O'Donovan C","Konig B","Turecki G","Hoffmann P","Stopkova P","Rybakowski JK","Alda M","Kittel-Schneider S","Witt SH","Pisanu C","DePaulo JR","Manchia M","Kuo PH","Bengesser S","Coombes BJ","Hashimoto R","Slaney CM","Landen M","Herms S","Fullerton JM","Bellivier F","Frisen L","Leckband SG","McElroy SL","Gard S","Batzler A","Grof P","Czerski PM","Schulze TG","Schofield PR","Schweizer BW","Reif A","Kelsoe JR","Goes FS","Osby U","Reininghaus E","Shekhtman T","Rietschel M","Maj M","Monteleone P","Nothen MM","Laje G","Shilling PD","Schalling M","Rouleau GA","Larrabee B","Grigoroiu-Serbanescu M","Biernacka JM","Clark SR","Del Zompo M","Pfennig A","Adli M","Severino G","Ardau R","Heilbronner U","Schubert KO","Mondimore FM","Forstner AJ","Millischer V","Dalkner N","Falkai P","Degenhardt F","Benabarre A","Martinsson L","Kassem L","Akula N","Lavebratt C","Bhattacharjee AK","Amare AT","Frye MA","Cruceanu C","Tortorella A","McMahon FJ","Kato T","Hou L","Aubry JM","Etain B","Jimenez E","Potash JB","Stamm T","Shimoda K","Arias B"],"additional_accession":[]},"is_claimable":false,"name":"Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.","description":"Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (<i>N</i> = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using <i>lassosum</i> and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; <i>p</i> value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; <i>p</i> value = 0.005)","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-21T23:36:36.207Z","creation":"2025-04-05T19:11:37.875Z"},"accession":"S-EPMC8740189","cross_references":{"pubmed":["36408127"],"doi":["10.1159/000519707"]}}