biostudies-literatureUnknown7(3-4)Coombes BJResponse to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (<i>N</i> = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using <i>lassosum</i> and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; <i>p</i> value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; <i>p</i> value = 0.005)Complex psychiatry80-89https://www.ebi.ac.uk/biostudies/studies/S-EPMC8740189biostudies-literatureAssociation of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.PMC8740189McCarthy MJOzaki NCichon SBaune BTGarnham JSFerensztajn-Rochowiak EMitjans MNievergelt CMVieta EKahn JPBauer MAkiyama KChen HCJamain SZandi PPSquassina ALeboyer MCervantes PKusumi IChillotti CSimhandl CBacklund LPapiol SMitchell PBNovak THauser JColom FO'Donovan CKonig BTurecki GHoffmann PStopkova PRybakowski JKAlda MKittel-Schneider SWitt SHPisanu CDePaulo JRManchia MKuo PHBengesser SCoombes BJHashimoto RSlaney CMLanden MHerms SFullerton JMBellivier FFrisen LLeckband SGMcElroy SLGard SBatzler AGrof PCzerski PMSchulze TGSchofield PRSchweizer BWReif AKelsoe JRGoes FSOsby UReininghaus EShekhtman TRietschel MMaj MMonteleone PNothen MMLaje GShilling PDSchalling MRouleau GALarrabee BGrigoroiu-Serbanescu MBiernacka JMClark SRDel Zompo MPfennig AAdli MSeverino GArdau RHeilbronner USchubert KOMondimore FMForstner AJMillischer VDalkner NFalkai PDegenhardt FBenabarre AMartinsson LKassem LAkula NLavebratt CBhattacharjee AKAmare ATFrye MACruceanu CTortorella AMcMahon FJKato THou LAubry JMEtain BJimenez EPotash JBStamm TShimoda KArias BfalseAssociation of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (<i>N</i> = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. PRSs for attention-deficit/hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia (SCZ) were computed using <i>lassosum</i> and in a model including all three PRSs and other covariates, and the PRS of ADHD (β = -0.14; 95% confidence interval [CI]: -0.24 to -0.03; <i>p</i> value = 0.010) and MDD (β = -0.16; 95% CI: -0.27 to -0.04; <i>p</i> value = 0.005)2021-01-01T00:00:00Z2021 Dec2025-04-21T23:36:36.207Z2025-04-05T19:11:37.875ZS-EPMC87401893640812710.1159/000519707