{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luchsinger JA"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","NIGMS NIH HHS"],"pagination":["2286-2292"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8740937"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(10)"],"pubmed_abstract":["<h4>Objective</h4>Type 2 diabetes is a risk factor for cognitive impairment. We examined the relation of glycemia, lipids, blood pressure (BP), hypertension history, and statin use with cognition in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).<h4>Research design and methods</h4>Cross-sectional analyses from GRADE at baseline examined the association of glycemia (hemoglobin A<sub>1c</sub> [HbA<sub>1c</sub>]), LDL, systolic BP (SBP) and diastolic BP (DBP), hypertension history, and statin use with cognition assessed by the Spanish English Verbal Learning Test, letter and animal fluency tests, and Digit Symbol Substitution Test (DSST).<h4>Results</h4>Among 5,047 GRADE participants, 5,018 (99.4%) completed cognitive assessments. Their mean age was 56.7 ± 10.0 years, and 36.4% were women. Mean diabetes duration was 4.0 ± 2.7 years. HbA<sub>1c</sub> was not related to cognition. Higher LDL was related to modestly worse DSST scores, whereas statin use was related to modestly better DSST scores. SBP between 120 and 139 mmHg and DBP between 80 and 89 mmHg were related to modestly better DSST scores. Hypertension history was not related to cognition.<h4>Conclusions</h4>In people with type 2 diabetes of a mean duration of <5 years, lower LDL and statin use were related to modestly better executive cognitive function. SBP levels in the range of 120-139 mmHg and DBP levels in the range of 80-89 mmHg, but not lower levels, were related to modestly better executive function. These differences may not be clinically significant."],"journal":["Diabetes care"],"pubmed_title":["Association of Glycemia, Lipids, and Blood Pressure With Cognitive Performance in People With Type 2 Diabetes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)."],"pmcid":["PMC8740937"],"funding_grant_id":["UL1 TR002378","UL1 TR002537","P30 DK111022","UL1 TR002535","UL1 TR000439","UL1 TR001449","UL1 TR001108","UL1 TR001409","P30 DK020572","UL1 TR002243","P30 DK092926","UL1 TR002489","P30 DK045735","UL1 TR002345","UL1 TR002548","P30 DK017047","U54 GM104940","UL1 TR000445","UL1 TR002529","U34 DK088043","P30 DK072476","U01 DK098246","P30 DK079626","P30 DK020541","P30 DK123704"],"pubmed_authors":["Estrada L","Pucchetti B","Schield E","Petrovitch H","Utzschneider KM","Rassouli N","Rhothisen S","Kuechenmeister L","Ngo L","DeManbey A","Burgess E","Schnurr-Breen L","Mech M","Maher-Albertelli M","Person S","Oropesa-Gonzalez L","Waltje A","Ballentine-Cargill K","Hurtado M","Satterwhite BM","Falck-Ytter C","Young L","Sanders C","Tsovian M","Montgomery BK","Howard D","Karshner T","Groessl E","Ye W","Herson M","Jenkins V","Frances S","Salam M","Kissel S","Ross A","Curtis JM","Morton L","Yamashita D","Manly JJ","McGill JB","Henry R","Morton S","Gallivan J","Kirpitch A","Joarder F","Scripsick E","Boeder S","Passi R","Ayala R","Hinkle N","Chatterjee R","Yepes M","Coe M","Chionh K","Brown-Friday J","Ellis E","Nelson R","Dostou J","Loveland A","Martinez J","Buse JB","Olson D","Sanders-Jones C","Myers J","Panos E","Scrymgeour A","Almeida H","Hsia DS","Bebu I","Arnold K","Johnson M","Gumpel K","Magenheimer E","Maggio C","Valencia W","Harindhanavudhi T","Alguard M","Meigs J","Killean T","Schell K","Kleeberger K","Perez M","Goodhall L","Phillips L","Lukin J","Aby-Daniel D","Bergenstal R","El-Haqq Z","Martin D","McConnell J","Martin C","Marks J","Hernandez S","Cherian A","Florez H","Gatcomb P","Stevens C","Dushkin A","Castro 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de la Torre S","Gong X","Evans Kreider K","Newman C","Saenger A","Doner Lotenberg L","Crandall JP","Burton K","Herman W","Thomassie A","Inzucchi S","Rasouli N","McGee P","Schweiger T","Riccio Veliz AK","King E","Puckett C","Mularski K","Tejada J","Perez-Rosas V","Seipel K","Zimmer RP","Steffes M","Aroda V","Campbell C","Morales Gomez B","Fuller G","Pirics V","Kumar A","Mather KJ"],"additional_accession":[]},"is_claimable":false,"name":"Association of Glycemia, Lipids, and Blood Pressure With Cognitive Performance in People With Type 2 Diabetes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).","description":"<h4>Objective</h4>Type 2 diabetes is a risk factor for cognitive impairment. We examined the relation of glycemia, lipids, blood pressure (BP), hypertension history, and statin use with cognition in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).<h4>Research design and methods</h4>Cross-sectional analyses from GRADE at baseline examined the association of glycemia (hemoglobin A<sub>1c</sub> [HbA<sub>1c</sub>]), LDL, systolic BP (SBP) and diastolic BP (DBP), hypertension history, and statin use with cognition assessed by the Spanish English Verbal Learning Test, letter and animal fluency tests, and Digit Symbol Substitution Test (DSST).<h4>Results</h4>Among 5,047 GRADE participants, 5,018 (99.4%) completed cognitive assessments. Their mean age was 56.7 ± 10.0 years, and 36.4% were women. Mean diabetes duration was 4.0 ± 2.7 years. HbA<sub>1c</sub> was not related to cognition. Higher LDL was related to modestly worse DSST scores, whereas statin use was related to modestly better DSST scores. SBP between 120 and 139 mmHg and DBP between 80 and 89 mmHg were related to modestly better DSST scores. Hypertension history was not related to cognition.<h4>Conclusions</h4>In people with type 2 diabetes of a mean duration of <5 years, lower LDL and statin use were related to modestly better executive cognitive function. SBP levels in the range of 120-139 mmHg and DBP levels in the range of 80-89 mmHg, but not lower levels, were related to modestly better executive function. These differences may not be clinically significant.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-22T21:48:09.782Z","creation":"2025-02-19T01:27:07.687Z"},"accession":"S-EPMC8740937","cross_references":{"pubmed":["34285097"],"doi":["10.2337/dc20-2858"]}}