{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang YP"],"funding":["NCATS NIH HHS","NIAMS NIH HHS","NIH HHS"],"pagination":["1458-1469"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8742287"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(23-24)"],"pubmed_abstract":["<i>In vivo</i> bioreactors are a promising approach for engineering vascularized autologous bone grafts to repair large bone defects. In this pilot parametric study, we first developed a three-dimensional (3D) printed scaffold uniquely designed to accommodate inclusion of a vascular bundle and facilitate growth factor delivery for accelerated vascular invasion and ectopic bone formation. Second, we established a new sheep deep circumflex iliac artery (DCIA) model as an <i>in vivo</i> bioreactor for engineering a vascularized bone graft and evaluated the effect of implantation duration on ectopic bone formation. Third, after 8 weeks of implantation around the DCIA, we transplanted the prevascularized bone graft to a 5 cm segmental bone defect in the sheep tibia, using the custom 3D printed "],"journal":["Tissue engineering. Part A"],"pubmed_title":["Investigation of a Prevascularized Bone Graft for Large Defects in the Ovine Tibia."],"pmcid":["PMC8742287"],"funding_grant_id":["R01 AR074458","K01 OD022982","R01 AR057837","U01 AR069395","R01 AR072613","L30 TR002126"],"pubmed_authors":["Lui E","Labus KM","Li J","McGilvray K","Palmer RH","Gadomski BC","Kim S","Stewart H","Maloney W","Regan D","Gardner MJ","Bruyas A","Yang YP","Moeinzadeh S","Puttlitz CM","Nelson B","Stahl A","Easley J"],"additional_accession":[]},"is_claimable":false,"name":"Investigation of a Prevascularized Bone Graft for Large Defects in the Ovine Tibia.","description":"<i>In vivo</i> bioreactors are a promising approach for engineering vascularized autologous bone grafts to repair large bone defects. In this pilot parametric study, we first developed a three-dimensional (3D) printed scaffold uniquely designed to accommodate inclusion of a vascular bundle and facilitate growth factor delivery for accelerated vascular invasion and ectopic bone formation. Second, we established a new sheep deep circumflex iliac artery (DCIA) model as an <i>in vivo</i> bioreactor for engineering a vascularized bone graft and evaluated the effect of implantation duration on ectopic bone formation. Third, after 8 weeks of implantation around the DCIA, we transplanted the prevascularized bone graft to a 5 cm segmental bone defect in the sheep tibia, using the custom 3D printed ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-26T09:47:12.842Z","creation":"2025-04-06T13:08:39.565Z"},"accession":"S-EPMC8742287","cross_references":{"pubmed":["33858216"],"doi":["10.1089/ten.TEA.2020.0347","10.1089/ten.tea.2020.0347"]}}