biostudies-literatureFleseriu MIntramural NIH HHSNIDDK NIH HHSNCI NIH HHS847-875https://www.ebi.ac.uk/biostudies/studies/S-EPMC8743006biostudies-literatureUnknown9(12)Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term management to optimise patient outcomes. The Pituitary Society convened a consensus workshop comprising more than 50 academic researchers and clinical experts to discuss the application of recent evidence to clinical practice. In advance of the virtual meeting, data from 2015 to present about screening and diagnosis; surgery, medical, and radiation therapy; and disease-related and treatment-related complications of Cushing's disease summarised in recorded lectures were reviewed by all participants. During the meeting, concise summaries of the recorded lectures were presented, followed by small group breakout discussions. Consensus opinions from each group were collated into a draft document, which was reviewed and approved by all participants. Recommendations regarding use of laboratory tests, imaging, and treatment options are presented, along with algorithms for diagnosis of Cushing's syndrome and management of Cushing's disease. Topics considered most important to address in future research are also identified.The lancet. Diabetes & endocrinologyConsensus on diagnosis and management of Cushing's disease: a guideline update.PMC8743006K23 DK082617T32 DK007682T32 DK007770Z01 HD008833P30 CA008748ZIA HD008920Biller BMKGrossman APivonello RBoguszewski CLTabarin AKaiser UBGadelha MFleseriu MStratakis CAVila GKaravitaki NNewell-Price JGiustina AFindling JWebb SMBuchfelder MCarmichael JDTsagarakis SBronstein MDZatelli MCCastinetti FHo KReincke MLacroix AMortini PBiermasz NRKelly DFMelmed SRaff HGeer EBMcCormack ABancos IKatznelson LSwearingen BShimon IAuchus RTheodoropoulou MChanson PNieman LTakahashi YIoachimescu AGPereira AMScaroni CVarlamov EVBen-Shlomo APetersenn SGurnell MBertherat JSalvatori RValassi EMolitch MCasanueva FFWass JfalseConsensus on diagnosis and management of Cushing's disease: a guideline update.Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term management to optimise patient outcomes. The Pituitary Society convened a consensus workshop comprising more than 50 academic researchers and clinical experts to discuss the application of recent evidence to clinical practice. In advance of the virtual meeting, data from 2015 to present about screening and diagnosis; surgery, medical, and radiation therapy; and disease-related and treatment-related complications of Cushing's disease summarised in recorded lectures were reviewed by all participants. During the meeting, concise summaries of the recorded lectures were presented, followed by small group breakout discussions. Consensus opinions from each group were collated into a draft document, which was reviewed and approved by all participants. Recommendations regarding use of laboratory tests, imaging, and treatment options are presented, along with algorithms for diagnosis of Cushing's syndrome and management of Cushing's disease. Topics considered most important to address in future research are also identified.2021-01-01T00:00:00Z2021 Dec2025-04-03T21:30:50.333Z2025-04-03T21:30:50.333ZS-EPMC87430063468760110.1016/s2213-8587(21)00235-710.1016/S2213-8587(21)00235-7