biostudies-literatureUnknown13(12)Zhu Y<h4>Background</h4>A diversity of surgical strategies are used to treat Marfan syndrome patients with aortic disease. We sought to evaluate the long-term efficiency of aortic root replacement (ARR) for patients with Marfan syndrome.<h4>Methods</h4>Data were collected from 131 patients with Marfan syndrome and aortic disease who underwent ARR in our center. We retrospectively analyzed the long-term outcomes of these patients, among whom 68 had been diagnosed with aortic aneurysm (AA) and had undergone ARR. The remaining 63 patients had aortic dissection (AD); of these, 35 underwent ARR for limited ascending AD, while the others underwent ARR and total arch replacement combined with frozen elephant trunk (FET). Risk factors for survival and reoperation were identified.<h4>Results</h4>The opeJournal of thoracic disease6779-6789https://www.ebi.ac.uk/biostudies/studies/S-EPMC8743404biostudies-literatureLong-term outcomes after aortic root replacement for patients with Marfan syndrome.PMC8743404Ma RZhu YXiao YWang YJian ZfalseLong-term outcomes after aortic root replacement for patients with Marfan syndrome.<h4>Background</h4>A diversity of surgical strategies are used to treat Marfan syndrome patients with aortic disease. We sought to evaluate the long-term efficiency of aortic root replacement (ARR) for patients with Marfan syndrome.<h4>Methods</h4>Data were collected from 131 patients with Marfan syndrome and aortic disease who underwent ARR in our center. We retrospectively analyzed the long-term outcomes of these patients, among whom 68 had been diagnosed with aortic aneurysm (AA) and had undergone ARR. The remaining 63 patients had aortic dissection (AD); of these, 35 underwent ARR for limited ascending AD, while the others underwent ARR and total arch replacement combined with frozen elephant trunk (FET). Risk factors for survival and reoperation were identified.<h4>Results</h4>The ope2021-01-01T00:00:00Z2021 Dec2025-04-19T20:34:06.678Z2025-04-19T20:34:06.678ZS-EPMC87434043507036210.21037/jtd-21-577