{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(11)"],"submitter":["Barona-Gomez F"],"funding":["Consejo Nacional de Ciencia y Tecnología","Newton Fund"],"pubmed_abstract":["Understanding the evolution of the SARS-CoV-2 virus in various regions of the world during the Covid-19 pandemic is essential to help mitigate the effects of this devastating disease. We describe the phylogenomic and population genetic patterns of the virus in Mexico during the pre-vaccination stage, including asymptomatic carriers. A real-time quantitative PCR screening and phylogenomic reconstructions directed at sequence/structure analysis of the spike glycoprotein revealed mutation of concern E484K in genomes from central Mexico, in addition to the nationwide prevalence of the imported variant 20C/S:452R (B.1.427/9). Overall, the detected variants in Mexico show spike protein mutations in the N-terminal domain (i.e. R190M), in the receptor-binding motif (i.e. T478K, E484K), within the "],"journal":["Microbial genomics"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8743546"],"repository":["biostudies-literature"],"pubmed_title":["Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms."],"pmcid":["PMC8743546"],"funding_grant_id":["180631","313075","CATEDRAS"],"pubmed_authors":["Cruz-Perez A","Garcia-Sepulveda CA","Plisson F","Garcia-Gonzalez OP","Perez-Abreu R","Diaz-Valenzuela E","Cibrian-Jaramillo A","Sanchez-Flores A","Vega-Magana N","Delaye L","Bernal-Silva S","Munoz-Valle JF","Comas-Garcia A","Barona-Gomez F","Diaz-Sanchez M","Valencia-Valdespino FJ"],"additional_accession":[]},"is_claimable":false,"name":"Phylogenomics and population genomics of SARS-CoV-2 in Mexico during the pre-vaccination stage reveals variants of interest B.1.1.28.4 and B.1.1.222 or B.1.1.519 and the nucleocapsid mutation S194L associated with symptoms.","description":"Understanding the evolution of the SARS-CoV-2 virus in various regions of the world during the Covid-19 pandemic is essential to help mitigate the effects of this devastating disease. We describe the phylogenomic and population genetic patterns of the virus in Mexico during the pre-vaccination stage, including asymptomatic carriers. A real-time quantitative PCR screening and phylogenomic reconstructions directed at sequence/structure analysis of the spike glycoprotein revealed mutation of concern E484K in genomes from central Mexico, in addition to the nationwide prevalence of the imported variant 20C/S:452R (B.1.427/9). Overall, the detected variants in Mexico show spike protein mutations in the N-terminal domain (i.e. R190M), in the receptor-binding motif (i.e. T478K, E484K), within the ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-08T03:26:49.324Z","creation":"2022-02-11T15:07:42.104Z"},"accession":"S-EPMC8743546","cross_references":{"pubmed":["34846283"],"doi":["10.1099/mgen.0.000684"]}}