{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(11)"],"submitter":["Young BC"],"funding":["department of health","Medical Research Council","wellcome trust","National Institute for Health Research (NIHR)","fondation mérieux","Wellcome Trust","nihr oxford biomedical research centre"],"pubmed_abstract":["<i>Staphylococcus aureus</i> is a major bacterial pathogen in humans, and a dominant cause of severe bloodstream infections. Globally, antimicrobial resistance (AMR) in <i>S. aureus</i> remains challenging. While human risk factors for infection have been defined, contradictory evidence exists for the role of bacterial genomic variation in <i>S. aureus</i> disease. To investigate the contribution of bacterial lineage and genomic variation to the development of bloodstream infection, we undertook a genome-wide association study comparing bacteria from 1017 individuals with bacteraemia to 984 adults with asymptomatic <i>S. aureus</i> nasal carriage. Within 984 carriage isolates, we also compared healthcare-associated (HA) carriage with community-associated (CA) carriage. All major global lin"],"journal":["Microbial genomics"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8743558"],"repository":["biostudies-literature"],"pubmed_title":["Antimicrobial resistance determinants are associated with &lt;i&gt;Staphylococcus aureus&lt;/i&gt; bacteraemia and adaptation to the healthcare environment: a bacterial genome-wide association study."],"pmcid":["PMC8743558"],"funding_grant_id":["Grant 101611/Z/13/Z","Grant 101237/Z/13/B","MR/K023985/1","101237/Z/13/Z","HDR-9006","NF-SI-0508-10279","101611/Z/13/Z","NIHR200239","203141/Z/16/Z","grant HICF-T5-358","WT098615/Z/12/Z","CL-2017-13-009","101237/Z/13/B","HPRU-2012-10041"],"pubmed_authors":["Peto TE","Godwin H","Quan TP","Wilson DJ","Tilley R","Llewelyn MJ","Charlesworth J","Scarborough M","Young BC","Gordon NC","Knox K","Oakley S","Price JR","Fung R","Miller R","Earle S","Dunn L","Walker AS","Cole K","Votintseva A","Wu CH","Crook DW","Liu E"],"additional_accession":[]},"is_claimable":false,"name":"Antimicrobial resistance determinants are associated with &lt;i&gt;Staphylococcus aureus&lt;/i&gt; bacteraemia and adaptation to the healthcare environment: a bacterial genome-wide association study.","description":"<i>Staphylococcus aureus</i> is a major bacterial pathogen in humans, and a dominant cause of severe bloodstream infections. Globally, antimicrobial resistance (AMR) in <i>S. aureus</i> remains challenging. While human risk factors for infection have been defined, contradictory evidence exists for the role of bacterial genomic variation in <i>S. aureus</i> disease. To investigate the contribution of bacterial lineage and genomic variation to the development of bloodstream infection, we undertook a genome-wide association study comparing bacteria from 1017 individuals with bacteraemia to 984 adults with asymptomatic <i>S. aureus</i> nasal carriage. Within 984 carriage isolates, we also compared healthcare-associated (HA) carriage with community-associated (CA) carriage. All major global lin","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2026-05-07T19:43:56.867Z","creation":"2022-02-11T15:07:47.566Z"},"accession":"S-EPMC8743558","cross_references":{"pubmed":["34812717"],"doi":["10.1099/mgen.0.000700"]}}