biostudies-literatureUnknown7(11)Young BCdepartment of healthMedical Research Councilwellcome trustNational Institute for Health Research (NIHR)fondation mérieuxWellcome Trustnihr oxford biomedical research centre<i>Staphylococcus aureus</i> is a major bacterial pathogen in humans, and a dominant cause of severe bloodstream infections. Globally, antimicrobial resistance (AMR) in <i>S. aureus</i> remains challenging. While human risk factors for infection have been defined, contradictory evidence exists for the role of bacterial genomic variation in <i>S. aureus</i> disease. To investigate the contribution of bacterial lineage and genomic variation to the development of bloodstream infection, we undertook a genome-wide association study comparing bacteria from 1017 individuals with bacteraemia to 984 adults with asymptomatic <i>S. aureus</i> nasal carriage. Within 984 carriage isolates, we also compared healthcare-associated (HA) carriage with community-associated (CA) carriage. All major global linMicrobial genomicshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC8743558biostudies-literatureAntimicrobial resistance determinants are associated with <i>Staphylococcus aureus</i> bacteraemia and adaptation to the healthcare environment: a bacterial genome-wide association study.PMC8743558Grant 101611/Z/13/ZGrant 101237/Z/13/BMR/K023985/1101237/Z/13/ZHDR-9006NF-SI-0508-10279101611/Z/13/ZNIHR200239203141/Z/16/Zgrant HICF-T5-358WT098615/Z/12/ZCL-2017-13-009101237/Z/13/BHPRU-2012-10041Peto TEGodwin HQuan TPWilson DJTilley RLlewelyn MJCharlesworth JScarborough MYoung BCGordon NCKnox KOakley SPrice JRFung RMiller REarle SDunn LWalker ASCole KVotintseva AWu CHCrook DWLiu EfalseAntimicrobial resistance determinants are associated with <i>Staphylococcus aureus</i> bacteraemia and adaptation to the healthcare environment: a bacterial genome-wide association study.<i>Staphylococcus aureus</i> is a major bacterial pathogen in humans, and a dominant cause of severe bloodstream infections. Globally, antimicrobial resistance (AMR) in <i>S. aureus</i> remains challenging. While human risk factors for infection have been defined, contradictory evidence exists for the role of bacterial genomic variation in <i>S. aureus</i> disease. To investigate the contribution of bacterial lineage and genomic variation to the development of bloodstream infection, we undertook a genome-wide association study comparing bacteria from 1017 individuals with bacteraemia to 984 adults with asymptomatic <i>S. aureus</i> nasal carriage. Within 984 carriage isolates, we also compared healthcare-associated (HA) carriage with community-associated (CA) carriage. All major global lin2021-01-01T00:00:00Z2021 Nov2026-05-07T19:43:56.867Z2022-02-11T15:07:47.566ZS-EPMC87435583481271710.1099/mgen.0.000700