{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["46(6)"],"submitter":["Fang Z"],"pubmed_abstract":["<h4>Background</h4>Previous studies have reported that disturbance of endogenous circadian rhythms enhances the chance of hypertension and suggested that circadian clock genes could have a crucial function in the onset of the disease. This case-control study was aimed to investigate the association of the mRNA expression of aryl hydrocarbon receptor nuclear translocator like (Arntl), clock circadian regulator (Clock), and period circadian regulators 1 and 2 (Per1 and Per2) with hypertension and blood pressure levels.<h4>Methods</h4>A total of 172 subjects were recruited in this study, including 86 hypertension and 86 nonhypertension controls. The mRNA expression levels in peripheral blood mononuclear cells were determined by real-time quantitative polymerase chain reaction. The differences"],"journal":["Kidney & blood pressure research"],"pagination":["741-748"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8743905"],"repository":["biostudies-literature"],"pubmed_title":["Downregulation of Arntl mRNA Expression in Women with Hypertension: A Case-Control Study."],"pmcid":["PMC8743905"],"pubmed_authors":["Fang Z","Yao Y","Zhu L","Chen Y","Jin Y","Chang W"],"additional_accession":[]},"is_claimable":false,"name":"Downregulation of Arntl mRNA Expression in Women with Hypertension: A Case-Control Study.","description":"<h4>Background</h4>Previous studies have reported that disturbance of endogenous circadian rhythms enhances the chance of hypertension and suggested that circadian clock genes could have a crucial function in the onset of the disease. This case-control study was aimed to investigate the association of the mRNA expression of aryl hydrocarbon receptor nuclear translocator like (Arntl), clock circadian regulator (Clock), and period circadian regulators 1 and 2 (Per1 and Per2) with hypertension and blood pressure levels.<h4>Methods</h4>A total of 172 subjects were recruited in this study, including 86 hypertension and 86 nonhypertension controls. The mRNA expression levels in peripheral blood mononuclear cells were determined by real-time quantitative polymerase chain reaction. The differences","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-04-08T12:09:21.983Z","creation":"2022-02-11T15:13:25.358Z"},"accession":"S-EPMC8743905","cross_references":{"pubmed":["34515147"],"doi":["10.1159/000518669"]}}