biostudies-literatureUnknown46(6)Fang Z<h4>Background</h4>Previous studies have reported that disturbance of endogenous circadian rhythms enhances the chance of hypertension and suggested that circadian clock genes could have a crucial function in the onset of the disease. This case-control study was aimed to investigate the association of the mRNA expression of aryl hydrocarbon receptor nuclear translocator like (Arntl), clock circadian regulator (Clock), and period circadian regulators 1 and 2 (Per1 and Per2) with hypertension and blood pressure levels.<h4>Methods</h4>A total of 172 subjects were recruited in this study, including 86 hypertension and 86 nonhypertension controls. The mRNA expression levels in peripheral blood mononuclear cells were determined by real-time quantitative polymerase chain reaction. The differencesKidney & blood pressure research741-748https://www.ebi.ac.uk/biostudies/studies/S-EPMC8743905biostudies-literatureDownregulation of Arntl mRNA Expression in Women with Hypertension: A Case-Control Study.PMC8743905Fang ZYao YZhu LChen YJin YChang WfalseDownregulation of Arntl mRNA Expression in Women with Hypertension: A Case-Control Study.<h4>Background</h4>Previous studies have reported that disturbance of endogenous circadian rhythms enhances the chance of hypertension and suggested that circadian clock genes could have a crucial function in the onset of the disease. This case-control study was aimed to investigate the association of the mRNA expression of aryl hydrocarbon receptor nuclear translocator like (Arntl), clock circadian regulator (Clock), and period circadian regulators 1 and 2 (Per1 and Per2) with hypertension and blood pressure levels.<h4>Methods</h4>A total of 172 subjects were recruited in this study, including 86 hypertension and 86 nonhypertension controls. The mRNA expression levels in peripheral blood mononuclear cells were determined by real-time quantitative polymerase chain reaction. The differences2021-01-01T00:00:00Z20212026-04-08T12:09:21.983Z2022-02-11T15:13:25.358ZS-EPMC87439053451514710.1159/000518669