biostudies-literatureKleckner ASMaryland Department of Health's Cigarette Restitution Fund ProgramAmerican Cancer SocietyMaryland Department of Health's Cigarette Restitution Fund ProgramNational Cancer InstituteNCI NIH HHS184https://www.ebi.ac.uk/biostudies/studies/S-EPMC8747418biostudies-literatureUnknown14(1)Cancer-related fatigue is a prevalent and debilitating condition that persists for years into survivorship. Studies evaluating both fish oil supplementation on fatigue and associations between fish oil consumption and fatigue have shown mixed effects; it is unknown what factors contribute to these differential effects. Herein, we investigate whether the nutritional status of cancer survivors was associated with serum omega-3 concentration or change in serum omega-3s throughout a fish oil supplementation study, and then if any of these factors were associated with fatigue. Breast cancer survivors 4-36 months post-treatment with moderate-severe fatigue were randomized to take 6 g fish oil, 6 g soybean oil, or 3 g of each daily for 6 weeks. Baseline nutritional status was calculated using theNutrientsNutritional Status Predicts Fatty Acid Uptake from Fish and Soybean Oil Supplements for Treatment of Cancer-Related Fatigue: Results from a Phase II Nationwide Study.PMC8747418R03CA175599K07CA221931N/ACRP-19-175-06-COUNUG1CA189961T32CA102618P30CA134274Kleckner ASParker EAOntko MDemark-Wahnefried WJanelsins MCKleckner IRBelcher EKPadula GDAPeppone LJMustian KMCulakova EfalseNutritional Status Predicts Fatty Acid Uptake from Fish and Soybean Oil Supplements for Treatment of Cancer-Related Fatigue: Results from a Phase II Nationwide Study.Cancer-related fatigue is a prevalent and debilitating condition that persists for years into survivorship. Studies evaluating both fish oil supplementation on fatigue and associations between fish oil consumption and fatigue have shown mixed effects; it is unknown what factors contribute to these differential effects. Herein, we investigate whether the nutritional status of cancer survivors was associated with serum omega-3 concentration or change in serum omega-3s throughout a fish oil supplementation study, and then if any of these factors were associated with fatigue. Breast cancer survivors 4-36 months post-treatment with moderate-severe fatigue were randomized to take 6 g fish oil, 6 g soybean oil, or 3 g of each daily for 6 weeks. Baseline nutritional status was calculated using the2021-01-01T00:00:00Z2021 Dec2026-04-08T10:07:42.304Z2022-02-11T16:12:40.148ZS-EPMC87474183501105910.3390/nu14010184