biostudies-literatureNathan JDNIDDK NIH HHS1-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC8748311biostudies-literatureUnknown22(1)<h4>Background</h4>Total pancreatectomy with islet autotransplantation (TPIAT) is a viable option for treating debilitating recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) in adults and children. No data is currently available regarding variation in approach to operation.<h4>Methods</h4>We evaluated surgical techniques, islet isolation and infusion approaches, and outcomes and complications, comparing children (n = 84) with adults (n = 195) enrolled between January 2017 and April 2020 by 11 centers in the United States in the Prospective Observational Study of TPIAT (POST), which was launched in 2017 to collect standard history and outcomes data from patients undergoing TPIAT for RAP or CP.<h4>Results</h4>Children more commonly underwent splenectomy (100% versus 91%, p = 0Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT.PMC8748311R01 DK109124Kirchner VLara LFGardner TBAhmad SHodges JSWijkstrom MBellin MDEllery KConwell DLEaton ATrikudanathan GBeilman GJSingh VKPosselt AMorgan KNaziruddin BHe JNathan JDSchwarzenberg SJMokshagundam SPWalsh MYang YWitkowski PPruett TLFreeman MLAbu-El-Haija MChinnakotla SfalseSurgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT.<h4>Background</h4>Total pancreatectomy with islet autotransplantation (TPIAT) is a viable option for treating debilitating recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) in adults and children. No data is currently available regarding variation in approach to operation.<h4>Methods</h4>We evaluated surgical techniques, islet isolation and infusion approaches, and outcomes and complications, comparing children (n = 84) with adults (n = 195) enrolled between January 2017 and April 2020 by 11 centers in the United States in the Prospective Observational Study of TPIAT (POST), which was launched in 2017 to collect standard history and outcomes data from patients undergoing TPIAT for RAP or CP.<h4>Results</h4>Children more commonly underwent splenectomy (100% versus 91%, p = 02022-01-01T00:00:00Z2022 Jan2025-04-21T15:21:39.153Z2025-04-21T15:21:39.153ZS-EPMC87483113462055210.1016/j.pan.2021.09.011