{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Butala NM"],"funding":["NCATS NIH HHS","NHLBI NIH HHS"],"pagination":["97-106"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8748407"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145(2)"],"pubmed_abstract":["<h4>Background</h4>Differences in patient characteristics, changes in treatment algorithms, and advances in medical technology could each influence the applicability of older randomized trial results to contemporary clinical practice. The DAPT Study (Dual Antiplatelet Therapy) found that longer-duration DAPT decreased ischemic events at the expense of greater bleeding, but subsequent evolution in stent technology and clinical practice may attenuate the benefit of prolonged DAPT in a contemporary population. We evaluated whether the DAPT Study population is different from a contemporary population of US patients receiving percutaneous coronary intervention and estimated the treatment effect of extended-duration antiplatelet therapy after percutaneous coronary intervention in this more conte"],"journal":["Circulation"],"pubmed_title":["Estimation of DAPT Study Treatment Effects in Contemporary Clinical Practice: Findings From the EXTEND-DAPT Study."],"pmcid":["PMC8748407"],"funding_grant_id":["T32 HL007208","R01 HL136708","UL1 TR001863","KL2 TR001862"],"pubmed_authors":["Strom JB","Yeh RW","Mauri L","Faridi KF","Secemsky EA","Shen C","Tamez H","Gibson CM","Kereiakes DJ","Butala NM","Song Y","Curtis JP"],"additional_accession":[]},"is_claimable":false,"name":"Estimation of DAPT Study Treatment Effects in Contemporary Clinical Practice: Findings From the EXTEND-DAPT Study.","description":"<h4>Background</h4>Differences in patient characteristics, changes in treatment algorithms, and advances in medical technology could each influence the applicability of older randomized trial results to contemporary clinical practice. The DAPT Study (Dual Antiplatelet Therapy) found that longer-duration DAPT decreased ischemic events at the expense of greater bleeding, but subsequent evolution in stent technology and clinical practice may attenuate the benefit of prolonged DAPT in a contemporary population. We evaluated whether the DAPT Study population is different from a contemporary population of US patients receiving percutaneous coronary intervention and estimated the treatment effect of extended-duration antiplatelet therapy after percutaneous coronary intervention in this more conte","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-04T09:30:20.839Z","creation":"2025-04-04T09:30:20.839Z"},"accession":"S-EPMC8748407","cross_references":{"pubmed":["34743530"],"doi":["10.1161/circulationaha.121.056878","10.1161/CIRCULATIONAHA.121.056878"]}}