biostudies-literatureCosta BMCInstituto Nacional de Ciência e Tecnologia em BioanalíticaNIBIB NIH HHSConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São PauloNational Institutes of HealthNIH HHSNIGMS NIH HHS545-550https://www.ebi.ac.uk/biostudies/studies/S-EPMC8748415biostudies-literatureUnknown414(1)In this work, we demonstrate for the first time the design and fabrication of microchip electrophoresis devices containing cross-shaped channels and spiral electrodes around the separation channel for microchip electrophoresis and capacitively coupled contactless conductivity detection. The whole device was prepared in a digital light processing-based 3D printer in poly(ethylene glycol) diacrylate resin. Outstanding X-Y resolution of the customized 3D printer ensured the fabrication of 40-μm cross section channels. The spiral channels were filled with melted gallium to form conductive electrodes around the separation channel. We demonstrate the applicability of the device on the separation of sodium, potassium, and lithium cations by microchip electrophoresis. Graphical abstract.Analytical and bioanalytical chemistry3D-printed microchip electrophoresis device containing spiral electrodes for integrated capacitively coupled contactless conductivity detection.PMC87484152018/06478-3R01 EB027096465389/2014-7R15GM123405R15 GM123405Nordin GPBeauchamp MJCoelho AGda Silva JAFNielsen JBCosta BMCWoolley ATfalse3D-printed microchip electrophoresis device containing spiral electrodes for integrated capacitively coupled contactless conductivity detection.In this work, we demonstrate for the first time the design and fabrication of microchip electrophoresis devices containing cross-shaped channels and spiral electrodes around the separation channel for microchip electrophoresis and capacitively coupled contactless conductivity detection. The whole device was prepared in a digital light processing-based 3D printer in poly(ethylene glycol) diacrylate resin. Outstanding X-Y resolution of the customized 3D printer ensured the fabrication of 40-μm cross section channels. The spiral channels were filled with melted gallium to form conductive electrodes around the separation channel. We demonstrate the applicability of the device on the separation of sodium, potassium, and lithium cations by microchip electrophoresis. Graphical abstract.2022-01-01T00:00:00Z2022 Jan2025-04-21T15:16:59.857Z2025-04-21T15:16:59.857ZS-EPMC87484153426334610.1007/s00216-021-03494-2