{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Conway KM"],"funding":["NCBDD CDC HHS","NCATS NIH HHS","Centers for Disease Control and Prevention","ACL HHS","FDA HHS","NINDS NIH HHS"],"pagination":["193-202"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8752499"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["65(2)"],"pubmed_abstract":["<h4>Introduction/aims</h4>Scoliosis is a common comorbidity among individuals diagnosed with a dystrophinopathy. We examined associations between clinical predictors and scoliosis in childhood-onset dystrophinopathy.<h4>Methods</h4>The progression and treatment of scoliosis were obtained from data collected by the US population-based Muscular Dystrophy Surveillance, Tracking, and Research Network. Associations between loss of independent ambulation (LoA) and corticosteroid use and scoliosis outcomes (ages at or exceeding Cobb angle thresholds [10°, 20°, 30°]; surgery) were estimated using Kaplan-Meier curve estimation and extended Cox regression modeling.<h4>Results</h4>We analyzed curvature data for 513 of 1054 individuals ascertained. Overall, approximately one-half had at least one radi"],"journal":["Muscle & nerve"],"pubmed_title":["A population-based study of scoliosis among males diagnosed with a dystrophinopathy identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet)."],"pmcid":["PMC8752499"],"funding_grant_id":["DD000192","DD000191","DD000190","R01 NS104010","U54 NS053672","R21 TR003184","U01DD001248","U01DD001247","U01 DD000191","U01 DD000190","U01 DD000189","DD000189","U01 DD001248","R01 FD006071","DD000187","U01 DD001247","U24 NS107181","U01DD001242","U01 DD000187"],"pubmed_authors":["Mathews KD","Hung M","Romitti PA","Johnson N","Perlman S","Gedlinske A","Bounsanga J","Oleszek J","Butterfield R","Conway KM","Matthews D"],"additional_accession":[]},"is_claimable":false,"name":"A population-based study of scoliosis among males diagnosed with a dystrophinopathy identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet).","description":"<h4>Introduction/aims</h4>Scoliosis is a common comorbidity among individuals diagnosed with a dystrophinopathy. We examined associations between clinical predictors and scoliosis in childhood-onset dystrophinopathy.<h4>Methods</h4>The progression and treatment of scoliosis were obtained from data collected by the US population-based Muscular Dystrophy Surveillance, Tracking, and Research Network. Associations between loss of independent ambulation (LoA) and corticosteroid use and scoliosis outcomes (ages at or exceeding Cobb angle thresholds [10°, 20°, 30°]; surgery) were estimated using Kaplan-Meier curve estimation and extended Cox regression modeling.<h4>Results</h4>We analyzed curvature data for 513 of 1054 individuals ascertained. Overall, approximately one-half had at least one radi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-19T13:30:24.899Z","creation":"2025-04-19T13:30:24.899Z"},"accession":"S-EPMC8752499","cross_references":{"pubmed":["34787322"],"doi":["10.1002/mus.27464"]}}