biostudies-literatureConway KMNCBDD CDC HHSNCATS NIH HHSCenters for Disease Control and PreventionACL HHSFDA HHSNINDS NIH HHS193-202https://www.ebi.ac.uk/biostudies/studies/S-EPMC8752499biostudies-literatureUnknown65(2)<h4>Introduction/aims</h4>Scoliosis is a common comorbidity among individuals diagnosed with a dystrophinopathy. We examined associations between clinical predictors and scoliosis in childhood-onset dystrophinopathy.<h4>Methods</h4>The progression and treatment of scoliosis were obtained from data collected by the US population-based Muscular Dystrophy Surveillance, Tracking, and Research Network. Associations between loss of independent ambulation (LoA) and corticosteroid use and scoliosis outcomes (ages at or exceeding Cobb angle thresholds [10°, 20°, 30°]; surgery) were estimated using Kaplan-Meier curve estimation and extended Cox regression modeling.<h4>Results</h4>We analyzed curvature data for 513 of 1054 individuals ascertained. Overall, approximately one-half had at least one radiMuscle & nerveA population-based study of scoliosis among males diagnosed with a dystrophinopathy identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet).PMC8752499DD000192DD000191DD000190R01 NS104010U54 NS053672R21 TR003184U01DD001248U01DD001247U01 DD000191U01 DD000190U01 DD000189DD000189U01 DD001248R01 FD006071DD000187U01 DD001247U24 NS107181U01DD001242U01 DD000187Mathews KDHung MRomitti PAJohnson NPerlman SGedlinske ABounsanga JOleszek JButterfield RConway KMMatthews DfalseA population-based study of scoliosis among males diagnosed with a dystrophinopathy identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet).<h4>Introduction/aims</h4>Scoliosis is a common comorbidity among individuals diagnosed with a dystrophinopathy. We examined associations between clinical predictors and scoliosis in childhood-onset dystrophinopathy.<h4>Methods</h4>The progression and treatment of scoliosis were obtained from data collected by the US population-based Muscular Dystrophy Surveillance, Tracking, and Research Network. Associations between loss of independent ambulation (LoA) and corticosteroid use and scoliosis outcomes (ages at or exceeding Cobb angle thresholds [10°, 20°, 30°]; surgery) were estimated using Kaplan-Meier curve estimation and extended Cox regression modeling.<h4>Results</h4>We analyzed curvature data for 513 of 1054 individuals ascertained. Overall, approximately one-half had at least one radi2022-01-01T00:00:00Z2022 Feb2025-04-19T13:30:24.899Z2025-04-19T13:30:24.899ZS-EPMC87524993478732210.1002/mus.27464